Evidence map›Paper›PMID 32344823›Full record

ArticleInternational journal of molecular sciences2020

The Effects of Human BDH2 on the Cell Cycle, Differentiation, and Apoptosis and Associations with Leukemia Transformation in Myelodysplastic Syndrome.

Wen-Chi Yang, Sheng-Fung Lin, Shu-Chen Wang, Wan-Chi Tsai, Chun-Chieh Wu, Shih-Chi Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wen-Chi YangDivision of Hematology and Medical Oncology, Department of Internal Medicine, E-DA Hospital, Kaohsiung 824, Taiwan.ORCID 0000-0001-7062-5194
Sheng-Fung LinDivision of Hematology and Medical Oncology, Department of Internal Medicine, E-DA Hospital, Kaohsiung 824, Taiwan.
Shu-Chen WangDepartment of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Wan-Chi TsaiDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0002-4490-3581
Chun-Chieh WuDepartment of Pathology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Shih-Chi WuSchool of Medicine, China Medical University, Taichung 404, Taiwan.
Kaohsiung Medical University · TWE-Da Hospital · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron overload is related to leukemia transformation in myelodysplastic syndrome (MDS) patients. Siderophores help to transport iron. Type 2-hydroxybutyrate dehydrogenase (BDH2) is a rate-limiting factor in the biogenesis of siderophores. Using qRT-PCR, we analyze

Indexed as

AdultAgedAged, 80 and overApoptosisBone MarrowCell Cycle CheckpointsCell DifferentiationFemaleFerritinsGene Expression RegulationGene Expression Regulation, LeukemicHumansHydroxybutyrate DehydrogenaseLeukemia, Myeloid, AcuteLipocalin-2MaleBDH2 protein, humanFerritinsHydroxybutyrate DehydrogenaseLCN2 protein, humanLipocalin-2Neoplasm ProteinsRNA, MessengerRNA, NeoplasmRNA, Small Interferingacute leukemiaBDH2iron metabolismLCN2myelodysplastic syndrome (MDS)

Identifiers

PMID32344823
PMCPMC7246807
OpenAlexW3020579325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.