Evidence map›Paper›PMID 32344789›Full record

ArticleJournal of clinical medicine2020

Dupilumab for the Treatment of Atopic Dermatitis in an Austrian Cohort-Real-Life Data Shows Rosacea-Like Folliculitis.

Tamara Quint, Patrick M Brunner, Christoph Sinz, Irene Steiner, Robin Ristl, Kornelia Vigl, Susanne Kimeswenger, Katharina Neubauer, Detlev Pirkhammer, Martin Zikeli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target.American journal of clinical dermatology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. A Literature Review of Real-World Effectiveness and Safety of Dupilumab for Atopic Dermatitis.JID innovations : skin science from molecules to population health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Tamara QuintDepartment of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.
Patrick M BrunnerDepartment of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-3488-3345
Christoph SinzDepartment of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5589-1865
Irene SteinerInstitute of Medical Statistics, Medical University Vienna, 1090 Vienna, Austria.
Robin RistlInstitute of Medical Statistics, Medical University Vienna, 1090 Vienna, Austria.
Kornelia ViglDepartment of Dermatology, Rudolfstiftung City Hospital, 1030 Vienna, Austria.
Susanne KimeswengerDepartment of Dermatology, Kepler University Hospital, 4020 Linz, Austria.ORCID 0000-0002-0443-8558
Katharina NeubauerDepartment of Dermatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Detlev PirkhammerDepartment of Dermatology, Rudolfstiftung City Hospital, 1030 Vienna, Austria.
Martin ZikeliDepartment of Dermatology, Wiener Neustadt Public Hospital, 2700 Wiener Neustadt, Austria.
Wolfram HoetzeneckerDepartment of Dermatology, Kepler University Hospital, 4020 Linz, Austria.
Norbert ReiderDepartment of Dermatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-7666-8566
Christine BangertDepartment of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.
Medical University of Vienna · ATInnsbruck Medical University · ATRudolfinerhaus Hospital · ATStatistics Austria · ATFachhochschule Wiener Neustadt · ATJohannes Kepler University of Linz · ATKepler Universitätsklinikum · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dupilumab is the first biological treatment approved for moderate-to-severe atopic dermatitis (AD). Efficacy and safety have been demonstrated in clinical trials, but real-life data is still limited. The objective of this study was to retrospectively evaluate Dupilumab treatment in AD patients in a real-life clinical setting. Effectiveness and safety outcomes were collected at baseline and after 2, 6, 10, 24, 39, and 52 weeks by using clinical scores for disease activity, as well as serological markers. Ninety-four patients from five dermatological hospitals were included. After 24 weeks of treatment, the median Investigator Global Assessment (IGA) and Eczema Area and Severity Index (EASI) showed a significant reduction compared to baseline (3.9 ± 0.7 vs. 1.4 ± 0.8 and 26.5 ± 12.5 vs. 6.4 ± 6.5). Interestingly, we observed rosacea-like folliculitis as an unexpected side effect in 6.4% of patients. Dupilumab proves to be an effective and well-tolerated treatment under real-life conditions. The occurrence of rosacea-like folliculitis warrants further mechanistic investigation.

Indexed as

atopic dermatitisbiologicalsconjunctivitisDupilumabrosacea-like folliculitis

Identifiers

PMID32344789
PMCPMC7230957
OpenAlexW3020126569

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.