Evidence map›Paper›PMID 32344757›Full record

ArticleInternational journal of molecular sciences2020

Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.

Klaus Geissler, Eva Jäger, Agnes Barna, Michael Gurbisz, Temeida Graf, Elmir Graf, Thomas Nösslinger, Michael Pfeilstöcker, Heinz Tüchler, Thamer Sliwa and 22 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Myeloid Neoplasms With Oligomonocytosis Exhibit Heterogenous Pathologic and Genetic Features.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Haematologica · 2023
    Article
  10. A Race to the Finish.The New England journal of medicine · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 11 institutions in 3 countries.

Klaus GeisslerMedical School, Sigmund Freud University, 1020 Vienna, Austria.
Eva JägerDepartment of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Agnes BarnaBlood Transfusion Service, Blood Transfusion Service for Upper Austria, Austrian Red Cross, 4020 Linz, Austria.
Michael GurbiszDepartment of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Temeida GrafDepartment of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.
Elmir GrafDepartment of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.
Thomas NösslingerDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Michael PfeilstöckerDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Heinz TüchlerDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Thamer SliwaDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Felix KeilDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Christoph GeisslerDepartment of Laboratory Medicine, Hospital Hietzing, 1130 Vienna, Austria.
Sonja HeiblDepartment of Internal Medicine IV, Hospital Wels-Grieskirchen, 4600 Wels, Austria.
Josef ThalerDepartment of Internal Medicine IV, Hospital Wels-Grieskirchen, 4600 Wels, Austria.
Sigrid Machherndl-SpandlDepartment of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.
Otto ZachDepartment of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.ORCID 0000-0002-1754-6849
Ansgar WeltermannDepartment of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.
Peter BettelheimDepartment of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.
Reinhard StauderInternal Medicine V with Hematology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-8993-9561
Armin ZebischDepartment of Internal Medicine, Division of Hematology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-4861-7021
Heinz SillDepartment of Internal Medicine, Division of Hematology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-0993-4371
Ilse SchwarzingerDepartment of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Bruno SchneeweissDepartment of Internal Medicine, Hospital Kirchdorf, 4560 Kirchdorf, Austria.
Leopold ÖhlerDepartment of Internal Medicine/Oncology, St. Josef Hospital, 1130 Vienna, Austria.
Ernst UlspergerDepartment of Internal Medicine, Hospital Horn, 3580 Horn, Austria.
Rajko KusecSchool of Medicine, University of Zagreb, University Hospital Dubrava, 10000 Zagreb, Croatia.
Ulrich GermingDepartment of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Wolfgang R SperrDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Paul KnöblDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Ulrich JägerDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9826-1062
Gregor HörmannCentral Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Peter ValentDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0456-5095
Medical University of Vienna · ATHanusch Hospital · ATOrdensklinikum Linz Barmherzige Schwestern · ATKlinik Hietzing · ATInnsbruck Medical University · ATKlinikum Wels-Grieskirchen · ATMedical University of Graz · ATAustrian Red Cross · ATHeinrich Heine University Düsseldorf · DESigmund Freud Privatuniversität Wien · ATUniversity of Zagreb · HR

Funding

Austrian Science Fund F4704-B20CSRD VA 1
6 · The paper itself

Abstract

Although the RAS-pathway has been implicated as an important driver in the pathogenesis of chronic myelomonocytic leukemia (CMML) a comprehensive study including molecular and functional analyses in patients with progression and transformation has not been performed. A close correlation between RASopathy gene mutations and spontaneous in vitro myeloid colony (CFU-GM) growth in CMML has been described. Molecular and/or functional analyses were performed in three cohorts of 337 CMML patients: in patients without (A,

Indexed as

MutationSignal TransductionCell Transformation, NeoplasticCytogenetic AnalysisDisease ProgressionGene Expression Regulation, LeukemicHumansLeukemia, Myelomonocytic, ChronicNeoplasm StagingNeoplastic Stem CellsPrognosisras ProteinsRetrospective Studiesras ProteinsAMLCFU-GMCMMLRAS-pathway mutations

Identifiers

PMID32344757
PMCPMC7215883
OpenAlexW3020403849

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.