Evidence map›Paper›PMID 32344753›Full record

ArticleVaccines2020

Construction and Immunogenicity of a Novel Multivalent Vaccine Prototype Based on Conserved Influenza Virus Antigens.

Anna Kirsteina, Inara Akopjana, Janis Bogans, Ilva Lieknina, Juris Jansons, Dace Skrastina, Tatjana Kazaka, Kaspars Tars, Irina Isakova-Sivak, Daria Mezhenskaya and 4 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Anna KirsteinaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Inara AkopjanaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Janis BogansLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Ilva LiekninaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Juris JansonsLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Dace SkrastinaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Tatjana KazakaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Kaspars TarsLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Irina Isakova-SivakDepartment of Virology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Daria MezhenskayaDepartment of Virology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Tatiana KotominaDepartment of Virology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Victoria MatyushenkoDepartment of Virology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Larisa RudenkoDepartment of Virology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Andris KazaksLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Latvian Biomedical Research and Study Centre · LVInstitute of Experimental Medicine · RU

Funding

European Regional Development Fund 1.1.1.1/16/A/054
6 · The paper itself

Abstract

Influenza, an acute, highly contagious respiratory disease, remains a significant threat to public health. More effective vaccination strategies aimed at inducing broad cross-protection not only against seasonal influenza variants, but also zoonotic and emerging pandemic influenza strains are urgently needed. A number of conserved protein targets to elicit such cross-protective immunity have been under investigation, with long alpha-helix (LAH) from hemagglutinin stalk and ectodomain of matrix protein 2 ion channel (M2e) being the most studied ones. Recently, we have reported the three-dimensional structure and some practical applications of LAH expressed in

Indexed as

conserved antigenshemagglutinin stalkinfluenzaM2e proteinprotectionvaccinesvirus-like particles

Identifiers

PMID32344753
PMCPMC7349063
OpenAlexW3019568760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.