Evidence map›Paper›PMID 32344633›Full record

ArticleNutrients2020

Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets.

Thao Duy Nguyen, Frida Fåk Hållenius, Xue Lin, Margareta Nyman, Olena Prykhodko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Nutrients · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thao Duy NguyenDepartment of Food Technology, Engineering and Nutrition, Kemicentrum, Lund University, PO Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0003-1326-3101
Frida Fåk HålleniusDepartment of Food Technology, Engineering and Nutrition, Kemicentrum, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Xue LinDepartment of Food Technology, Engineering and Nutrition, Kemicentrum, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Margareta NymanDepartment of Food Technology, Engineering and Nutrition, Kemicentrum, Lund University, PO Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0003-3660-2364
Olena PrykhodkoDepartment of Food Technology, Engineering and Nutrition, Kemicentrum, Lund University, PO Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0002-5788-9176
Lund University · SE

Funding

MEKONG 1000 SCHOLARSHIP (Vietnam) and PERSTORP AB (Sweden) None
6 · The paper itself

Abstract

Monobutyrin (MB) and monovalerin (MV), esters of short-chain fatty acids (SCFAs), have previously been shown to reduce liver cholesterol and inflammation in conventional rats fed high-fat diets. This study explored the potential effects of MB and MV in hypercholesterolemic apolipoprotein E-knockout (ApoE-/-) rats. ApoE-/- rats were fed three high-fat (HF) diets, pure or supplemented with MB or MV (1%), for 5 weeks. One group of conventional rats (C) was also fed the pure high-fat diet and another group of ApoE-/- rats a low-fat (LF) diet. Blood and liver lipids, urinary lactulose/mannitol, SCFAs (blood and brain), tight junction proteins (small intestine and brain), and inflammation-related markers (blood, brain, and liver) were analyzed. MV supplementation elevated serum high-density lipoprotein (HDL) cholesterol and valeric acid concentration (

Indexed as

AnimalsApolipoproteins EBiomarkersBody WeightBrainCytokinesDiet, High-FatFatty Acids, VolatileGene Expression RegulationGlyceridesIntestinal MucosaLipid MetabolismMaleMice, KnockoutOrgan SizePermeability1-butyrylglycerolApolipoproteins EBiomarkersCytokinesFatty Acids, VolatileGlyceridesHcar2 protein, ratReceptors, G-Protein-CoupledTight Junction Proteinsbutyric acidcholesterolgut–brain axisisovaleric acidSCFAsvaleric acid

Identifiers

PMID32344633
PMCPMC7230324
OpenAlexW3020276458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.