Evidence map›Paper›PMID 32344619›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Enhancing the Cellular Uptake and Antibacterial Activity of Rifampicin through Encapsulation in Mesoporous Silica Nanoparticles.

Paul Joyce, Hanna Ulmefors, Sajedeh Maghrebi, Santhni Subramaniam, Anthony Wignall, Silver Jõemetsa, Fredrik Höök, Clive A Prestidge

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

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  10. Regulation ofPharmaceutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Paul JoyceDepartment of Physics, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.ORCID 0000-0003-3619-7901
Hanna UlmeforsSchool of Pharmacy & Medical Sciences, University of South Australia, Adelaide, South Australia 5090, Australia.
Sajedeh MaghrebiSchool of Pharmacy & Medical Sciences, University of South Australia, Adelaide, South Australia 5090, Australia.
Santhni SubramaniamSchool of Pharmacy & Medical Sciences, University of South Australia, Adelaide, South Australia 5090, Australia.
Anthony WignallSchool of Pharmacy & Medical Sciences, University of South Australia, Adelaide, South Australia 5090, Australia.
Silver JõemetsaDepartment of Physics, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.ORCID 0000-0001-7957-8750
Fredrik HöökDepartment of Physics, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
Clive A PrestidgeSchool of Pharmacy & Medical Sciences, University of South Australia, Adelaide, South Australia 5090, Australia.
University of South Australia · AUChalmers University of Technology · SE

Funding

ÅForsk Foundation 16-463Australian Research Council Centre of Excellence in Bio-Nano Science and Technology ARC CE140100036
6 · The paper itself

Abstract

An urgent demand exists for the development of novel delivery systems that efficiently transport antibacterial agents across cellular membranes for the eradication of intracellular pathogens. In this study, the clinically relevant poorly water-soluble antibiotic, rifampicin, was confined within mesoporous silica nanoparticles (MSN) to investigate their ability to serve as an efficacious nanocarrier system against small colony variants of

Indexed as

antibioticsCaco-2fluorescence microscopyinfectionmesoporous silicananoparticlepermeabilitysmall colony variantsStaphylococcus aureustotal internal reflection

Identifiers

PMID32344619
PMCPMC7221943
OpenAlexW3018479728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.