Evidence map›Paper›PMID 32344538›Full record

ArticleCancers2020

Radiomics-Based Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy.

Elsa Parr, Qian Du, Chi Zhang, Chi Lin, Ahsan Kamal, Josiah McAlister, Xiaoying Liang, Kyle Bavitz, Gerard Rux, Michael Hollingsworth and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Bounding box-based 3D AI model for user-guided volumetric segmentation of pancreatic ductal adenocarcinoma on standard-of-care CTs.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Understanding the Conundrum of Pancreatic Cancer in the Omics Sciences Era.International journal of molecular sciences · 2024
    Review
  12. Article
  13. A clinical-radiomics nomogram based on dual-layer spectral detector CT to predict cancer stage in pancreatic ductal adenocarcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Multiparametric detection and outcome prediction of pancreatic cancer involving dual-energy CT, diffusion-weighted MRI, and radiomics.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Elsa ParrRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Qian DuBiological Sciences, University of Nebraska Lincoln, Lincoln, NE 68521, USA.
Chi ZhangBiological Sciences, University of Nebraska Lincoln, Lincoln, NE 68521, USA.
Chi LinRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-7279-0473
Ahsan KamalRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Josiah McAlisterRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Xiaoying LiangProton Institute, University of Florida, Jacksonville, FL 32206, USA.
Kyle BavitzRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Gerard RuxRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michael HollingsworthRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michael BaineRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-1163-7539
Dandan ZhengRadiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · USUniversity of Nebraska–Lincoln · USUniversity of Florida · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RIZZO, MATTHEW · 2016 to 2025
$42.8M
NIH HHS 2P50CA127297-06A1
6 · The paper itself

Abstract

(1) Background: Radiomics use high-throughput mining of medical imaging data to extract unique information and predict tumor behavior. Currently available clinical prediction models poorly predict treatment outcomes in pancreatic adenocarcinoma. Therefore, we used radiomic features of primary pancreatic tumors to develop outcome prediction models and compared them to traditional clinical models. (2) Methods: We extracted and analyzed radiomic data from pre-radiation contrast-enhanced CTs of 74 pancreatic cancer patients undergoing stereotactic body radiotherapy. A panel of over 800 radiomic features was screened to create overall survival and local-regional recurrence prediction models, which were compared to clinical prediction models and models combining radiomic and clinical information. (3) Results: A 6-feature radiomic signature was identified that achieved better overall survival prediction performance than the clinical model (mean concordance index: 0.66 vs. 0.54 on resampled cross-validation test sets), and the combined model improved the performance slightly further to 0.68. Similarly, a 7-feature radiomic signature better predicted recurrence than the clinical model (mean AUC of 0.78 vs. 0.66). (4) Conclusion: Overall survival and recurrence can be better predicted with models based on radiomic features than with those based on clinical features for pancreatic cancer.

Indexed as

pancreatic cancerprognosis predictionradiomicsSBRT

Identifiers

PMID32344538
PMCPMC7226523
OpenAlexW3019884544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.