Evidence map›Paper›PMID 32344323›Full record

ReviewCurrent opinion in neurobiology2020

Viral vectors for neuronal cell type-specific visualization and manipulations.

Yuanyuan Liu, Shane Hegarty, Carla Winter, Fan Wang, Zhigang He

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Yuanyuan LiuSomatosensation and Pain Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health (NIH), MD, USA.
Shane HegartyF. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Carla WinterF. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA; PhD Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
Fan WangDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Zhigang HeF. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: zhigang.he@childrens.harvard.edu.
Boston Children's Hospital · USDuke University · USHarvard University · USNational Institutes of Health · US

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ZHIGANG HE · 1998 to 2026
$21.3M
Somatosensation and pain ZIADE000757 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI LIU, YUANYUAN · 2020 to 2025
$7.4M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Cortical Signature and Modulation of PainR01NS109947 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HE, ZHIGANG, WANG, FAN · 2018 to 2022
$4.0M
Generating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species ApplicabilityU01MH109107 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG · 2015 to 2017
$2.2M
NEI NIH HHS P30 EY012196NICHD NIH HHS U54 HD090255NIMH NIH HHS U01 MH109107NINDS NIH HHS R01 NS109947
6 · The paper itself

Abstract

Characterizing neuronal cell types demands efficient strategies for specific labeling and manipulation of individual subtypes to dissect their connectivity and functions. Recombinant viral technology offers a powerful toolbox for targeted transgene expression in specific neuronal populations. In order to achieve cell type-specific targeting, exciting progress has been made to: alter viral tropisms, design rational delivery strategies, and drive selective expression patterns with engineered DNA sequences in viral genomes. For the latter case, emerging single-cell genomic analyses provide rich databases. In this review, we will summarize current status, and point out challenges, of using viral vectors for neuronal cell type-specific visualization and manipulations. With concerted efforts, progress will continue to be made toward developing viral vectors for the vast array of neuronal subtypes in the mammalian nervous system.

Indexed as

Genetic VectorsGene Transfer TechniquesAnimalsNeurons

Identifiers

PMID32344323
PMCPMC7484153
OpenAlexW3019278566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.