N-acetyl-cysteine may prevent COVID-19-associated cytokine storm and acute respiratory distress syndrome.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

1. Evaluation of the efficacy and safety of oral N-acetylcysteine in patients with COVID-19 receiving the routine antiviral and hydroxychloroquine protocol: A randomized controlled clinical trial.Immunity, inflammation and disease · 2023
   Article
2. N-acetylcysteine for prevention and treatment of COVID-19: Current state of evidence and future directions.Journal of infection and public health · 2022
   Review
3. Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19).Inflammopharmacology · 2022
   Review
4. The Renin-Angiotensin-Aldosterone System, Nitric Oxide, and Hydrogen Sulfide at the Crossroads of Hypertension and COVID-19: Racial Disparities and Outcomes.International journal of molecular sciences · 2022
   Review
5. Anti-inflammatory effects of N-Acetylcysteine and Elaeagnus angustifolia extract on acute lung injury induced by λ-carrageenan in rat.Inflammopharmacology · 2022
   Article
6. Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation.mBio · 2022
   Article
7. Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19.Signal transduction and targeted therapy · 2022
   Review
8. The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19.International immunopharmacology · 2021
   Review
9. Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: overlapping biology with cancer.RSC chemical biology · 2021
   Review
10. HBiomedicines · 2021
    Review
11. The Effect of COVID-19 on NF-κB and Neurological Manifestations of Disease.Molecular neurobiology · 2021
    Review
12. The signal pathways and treatment of cytokine storm in COVID-19.Signal transduction and targeted therapy · 2021
    Review
13. Pathogenesis and Management of COVID-19.Journal of xenobiotics · 2021
    Review
14. The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.Inflammopharmacology · 2021
    Review
15. Vitamins and other immune-supportive elements as cofactors for passing the COVID-19 pandemic.Beni-Suef University journal of basic and applied sciences · 2021
    Review
16. Clinical Experience, Pathophysiology, and Considerations in the Prophylaxis and Treatment of Hypercoagulopathy of COVID-19: A Review Study.Iranian journal of medical sciences · 2021
    Review
17. The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options.Microbial pathogenesis · 2021
    Review
18. COVID-19 and Oxidative Stress.Biochemistry. Biokhimiia · 2020
    Review
19. Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?Redox biology · 2020
    Review
20. Repurposing existing drugs for COVID-19: an endocrinology perspective.BMC endocrine disorders · 2020
    Article

Corrections and comments

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Authors and funding

2 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.