Evidence map›Paper›PMID 32344154›Full record

ArticleNeurobiology of disease2020

HIV and opiates dysregulate K

Aaron J Barbour, Kurt F Hauser, A Rory McQuiston, Pamela E Knapp

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
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  12. Frontiers in psychiatry · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aaron J BarbourDepartments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Kurt F HauserDepartments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
A Rory McQuistonDepartments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Pamela E KnappDepartments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA. Electronic address: Pamela.knapp@vcuhealth.org.
Virginia Commonwealth University · US

Funding

MOR and CCR5 interactive signaling mediates opiate and HIV-driven synaptodendritic injuryR01DA034231 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F, KNAPP, PAMELA E · 2013 to 2023
$5.4M
Mechanisms of Opiate Drug-HIV-Induced NeurodegenerationR01DA018633 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2005 to 2021
$4.4M
Glial Progenitors as Targets of HIV/Opiate InteractionsR01DA024461 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KNAPP, PAMELA E · 2007 to 2018
$3.9M
Regulation of HIV and opiate-directed synaptodendritic injury/death in striatumR01DA033200 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2013 to 2017
$2.1M
Selective vulnerability of discrete neural circuits in the striatum to HIV-opiate comorbidityR01DA045588 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2018 to 2022
$2.0M
Cells, synapses, and networks contributing to synchrony in the CNSR01MH107507 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCQUISTON, ADAM RORY · 2016 to 2020
$1.9M
Neuron-Glia Mechanisms & Interactions Underlying Opioid Abuse-HIV-1 ComorbidityK02DA027374 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2009 to 2018
$1.3M
Effect of pathogenic tau on entorhinal cortical inputs to dentate gyrus interneuronsR21AG055073 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCQUISTON, ADAM RORY · 2017 to 2018
$426k
Optical electrophysiology of human primary neurons: role of KCC2 in hyperexcitability induced by HIV-1, Tat, and gp120 and morphine exposureF31DA047195 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BARBOUR, AARON JOSEPH · 2018 to 2019
$60k
NIA NIH HHS R21 AG055073NIDA NIH HHS F31 DA047195NIDA NIH HHS K02 DA027374NIDA NIH HHS R01 DA018633NIDA NIH HHS R01 DA024461NIDA NIH HHS R01 DA033200NIDA NIH HHS R01 DA034231NIDA NIH HHS R01 DA045588NIMH NIH HHS R01 MH107507
6 · The paper itself

Abstract

Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic disruption is selectively vulnerable to viral and inflammatory factors released by infected/affected glia. Here, we demonstrate diminished K

Indexed as

Analgesics, OpioidAnimalsgamma-Aminobutyric AcidHIV-1Human Immunodeficiency Virus ProteinsHumansK Cl- CotransportersMaleMice, TransgenicMorphineNeural Stem CellsNeuronsSymportersAnalgesics, Opioidgamma-Aminobutyric AcidHuman Immunodeficiency Virus ProteinsK Cl- CotransportersMorphineSLC12A5 protein, humanSymportersArchon1C-C motif chemokine receptor 5 (CCR5)GABA(A) hyperpolarizationGCaMP6fIntracellular chloride homeostasisKCC2neuroHIVOpioid abuse

Identifiers

PMID32344154
PMCPMC7685173
OpenAlexW3017425702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.