Evidence map›Paper›PMID 32344063›Full record

ArticleNeuroImage2020

Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain.

Marta Čeko, Eleni Frangos, John Gracely, Emily Richards, Binquan Wang, Petra Schweinhardt, M Catherine Bushnell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  3. Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Marta ČekoInstitute of Cognitive Science, University of Colorado, Boulder, CO, USA. Electronic address: marta.ceko@colorado.edu.
Eleni FrangosNational Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, USA.
John GracelyNational Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, USA.
Emily RichardsNational Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, USA.
Binquan WangNational Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, USA.
Petra SchweinhardtThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada; Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada; Department of Chiropractic Medicine, Balgrist University Hospital and University of Zurich, Zurich, Switzerland.
M Catherine BushnellNational Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USUniversity of Colorado Boulder · USUniversity of Zurich · CH

Funding

Brain Mechanisms of Pain Processing and ModulationZIAAT000024 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI SHURTLEFF, DAVID · 2013 to 2024
$7.1M
Intramural NIH HHS ZIA AT000024
6 · The paper itself

Abstract

Differences in fMRI resting-state connectivity of the default mode network (DMN) seen in chronic pain patients are often interpreted as brain reorganization due to the chronic pain condition. Nevertheless, patients' pain at the time of fMRI might influence the DMN because pain, like cognitive stimuli, engages attentional mechanisms and cognitive engagement is known to alter DMN activity. Here, we aimed to dissociate the influence of chronic pain condition (trait) from the influence of current pain experience (state) on DMN connectivity in patients with fibromyalgia (FM). We performed resting-state fMRI scans to test DMN connectivity in FM patients and matched healthy controls in two separate cohorts: (1) in a cohort not experiencing pain during scanning (27 FM patients and 27 controls), (2) in a cohort with current clinical pain during scanning (16 FM patients and 16 controls). In FM patients without pain during scanning, the connectivity of the DMN did not differ significantly from controls. By contrast, FM patients with current clinical pain during the scan had significantly increased DMN connectivity to bilateral anterior insula (INS) similar to previous studies. Regression analysis showed a positive relationship between DMN-midINS connectivity and current pain. We therefore suggest that transient DMN disruptions due to current clinical pain during scanning (current pain state) may be a substantial contributor to DMN connectivity disruptions observed in chronic pain patients.

Indexed as

ConnectomeMagnetic Resonance ImagingAdultCerebral CortexChronic PainDefault Mode NetworkFemaleFibromyalgiaHumansMaleMiddle Aged

Identifiers

PMID32344063
PMCPMC8855626
OpenAlexW3020288201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.