Trial reportThe Journal of allergy and clinical immunology2020
Associations of α- and γ-tocopherol during early life with lung function in childhood.
Trial report in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Oxidized vitamin E metabolites during infancy and childhood asthma risk: too little, too much, or just right?American journal of respiratory and critical care medicine · 2026Article
- Early Life Food Desert Status Is Associated With Alpha and Gamma-Tocopherol Levels and Infant Lung Function.Pediatric pulmonology · 2026Article
- Diet Components, Immune Function and IgE-Mediated Food Allergy.Nutrients · 2025Review
- Innovative approaches to asthma treatment: harnessing nanoparticle technology.Discover nano · 2025Review
- Maternal supplementation with α-tocopherol inhibits the development of offspring food allergy, H1R signaling and ultimately anaphylaxis early in life.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Association of prenatal vitamin E levels with child asthma and wheeze.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Evaluation of the Prime Diet Quality Score from Early Childhood Through Mid-Adolescence.The Journal of nutrition · 2024Article
- Article
- Dysbiotic lung microbial communities of neonates from allergic mothers confer neonate responsiveness to suboptimal allergen.Frontiers in allergy · 2023Article
- Asthma, allergy and vitamin E: Current and future perspectives.Free radical biology & medicine · 2022Article
- Pilot scale production of functional foods using red palm olein: Antioxidant, vitamins' stability and sensory quality during storage.Saudi journal of biological sciences · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundTocopherol isoforms may regulate child lung growth and spirometric measures.
objectiveOur aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function.
methodsWe included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM
resultsThe median maternal second trimester α-T level was 63 μM (interquartile range = 47-82). The median early-childhood level was 25 μM (interquartile range = 20-33 μM). In the lowest tertile of early-childhood γ-T, children with a higher α-T level (per 10 μM) had a higher mid-childhood FEV
conclusionWhen γ-T levels were in the lowest tertile, a higher early-childhood α-T level was associated with better lung function at mid-childhood. Second trimester maternal plasma α-T concentration was 3-fold higher than in the adult nonpregnant female population.
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What OpenQuestion holds
Registered trials
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