ArticleFEBS open bio2020
Reduced levels of miR-485-5p in HPV-infected cervical cancer promote cell proliferation and enhance invasion ability.
Article in FEBS open bio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Ythdc1-p300-Klf5 Complex-Mediated Golgi Dysfunction Promotes Aortic Aneurysm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis.Functional & integrative genomics · 2023Article
- Long noncoding RNA LINC01419 promotes hepatocellular carcinoma malignancy by mediating miR-485-5p/LSM4 axis.The Kaohsiung journal of medical sciences · 2022Article
- MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Long noncoding RNA SNHG3 promotes glioma tumorigenesis by sponging miR-485-5p to upregulate LMX1B expression.The Kaohsiung journal of medical sciences · 2021Article
- E74-like factor 3 suppresses microRNA-485-5p transcription to trigger growth and metastasis of ovarian cancer cells with the involvement of CLDN4/Wnt/β-catenin axis.Saudi journal of biological sciences · 2021Article
- MiR-485 targets the DTX4 gene to regulate milk fat synthesis in bovine mammary epithelial cells.Scientific reports · 2021Article
Corrections and comments
- Retraction · 2023-05-23Duplication of/in Image · Investigation by Journal/Publisher · Investigation by Third Party · Paper Mill · Unreliable Results and/or Conclusions · · see also: https://pubpeer.com/publications/B200722A0B2B992C644F603A7A542F
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer (CC) is the most common gynecological malignancy, with high incidence and mortality rates in China. The microRNA miR-485-5p has previously been reported to serve as a negative regulator of tumorigenesis in breast cancer and hepatocellular carcinoma, and miR-485-5p has been observed to be differentially expressed between CC and normal control tissue. Here, we confirmed that miR-485-5p expression is lower in CC than in adjacent normal tissue and proceeded to investigate the effects of miR-485 on tumor behavior in CC cell lines. We report that miR-485-5p transcription is decreased in HPV-infected CC tissue, and levels of miR-485 in clinical samples are positively correlated with the 5-year overall survival rate. The Transwell assay showed that miR-485-5p inhibited cell invasion and migration but had no influence on apoptosis and cell proliferation. Using a luciferase reporter assay, we demonstrated that miR-485-5p partially abrogated cell migration and proliferation by targeting FLOT-1 mRNA. Transfection of HPV-infected cervical carcinoma cells with an adenovirus vector encoding human FLOT-1 partially diminished the inhibitory effects of miR-485 on cell invasion. Taken, together, these data demonstrated that miR-485-5p suppresses the invasion of cancer cells by targeting FLOT-1 in HPV-infected cervical carcinoma cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.