ArticleMovement disorders : official journal of the Movement Disorder Society2020
Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor.
Article in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging.Human brain mapping · 2021Pooled it
- Dual-tracer [Quantitative imaging in medicine and surgery · 2026Article
- Association of motor subtype and tremor type with Parkinson's disease progression: An exploratory longitudinal analysis.Journal of Parkinson's disease · 2025Article
- Changes in Action Tremor in Parkinson's Disease over Time: Clinical and Neuroimaging Correlates.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Multimodal Magnetic Resonance Findings in Parkinson's Disease With "Antecedent Essential Tremor": A Case Series of a Large Kindred.Neuropsychiatric disease and treatment · 2025Article
- Review
- Smaller Cerebellar Lobule VIIb is Associated with Tremor Severity in Parkinson's Disease.Cerebellum (London, England) · 2024Article
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Tremor-associated short tandem repeat intermediate and pathogenic expansions in familial essential tremor.Brain communications · 2024Article
- Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Large-scale networks changes in Wilson's disease associated with neuropsychiatric impairments: a resting-state functional magnetic resonance imaging study.BMC psychiatry · 2023Article
- Linking the cerebellum to Parkinson disease: an update.Nature reviews. Neurology · 2023Review
- Auto-Classification of Parkinson's Disease with Different Motor Subtypes Using Arterial Spin Labelling MRI Based on Machine Learning.Brain sciences · 2023Article
- Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis.Neurology · 2023Review
- Identifying and distinguishing of essential tremor and Parkinson's disease with grouped stability analysis based on searchlight-based MVPA.Biomedical engineering online · 2022Article
- A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- Anatomical texture patterns identify cerebellar distinctions between essential tremor and Parkinson's disease.Human brain mapping · 2021Article
- The Role of the Cerebellum in Tremor - Evidence from Neuroimaging.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Review
- A Radiomics Approach to Predicting Parkinson's Disease by Incorporating Whole-Brain Functional Activity and Gray Matter Structure.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundParkinson's disease (PD) and essential tremor (ET) are commonly encountered movement disorders. Pathophysiologic processes that localize to the cerebellum are described in both. There are limited studies investigating cerebellar structural changes in these conditions, largely because of inherent challenges in the efficiency of segmentation.
methodsWe applied a novel multiatlas cerebellar segmentation method to T1-weighted images in 282 PD and 111 essential tremor patients to define 26 cerebellar lobule volumes. The severity of postural and resting tremor in both populations and gait and postural instability in PD patients were defined using subscores of the UPDRS and Washington Heights-Inwood Genetic Study motor scales. These clinical measurements were related to lobule volume size. Multiple comparisons were controlled using a false discovery rate method.
resultsGroup differences were identified between ET and PD patients, with reductions in deep cerebellar nucleus volume in ET versus reduced lobule VI volume in PD. In ET patients, lobule VIII was negatively correlated with the severity of postural tremor. In PD patients, lobule IV was positively correlated with resting tremor and total tremor severity. We observed differences in cerebellar structure that localized to sensorimotor lobules of the cerebellum. Lobule volumes appeared to differentially relate to clinical symptoms, suggesting important clinicopathologic distinctions between these conditions. These results emphasize the role of the cerebellum in tremor symptoms and should foster future clinical and pathologic investigations of the sensorimotor lobules of the cerebellum. © 2020 International Parkinson and Movement Disorder Society.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.