ArticlePloS one2020
Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Associations between epilepsy-related polygenic risk and brain morphology in childhood.Brain : a journal of neurology · 2026Article
- Polygenic scores contribution to Parkinson's disease comorbidities.Brain communications · 2025Article
- Smoking and epilepsy in national health interview survey: a cross-sectional study.Frontiers in human neuroscience · 2025Article
- Article
- Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.Nature communications · 2024Article
- Dissecting the Shared Genetic Architecture of Common Epilepsies With Cortical Brain Morphology.Neurology. Genetics · 2024Article
- Unraveling the shared genetics of common epilepsies and general cognitive ability.medRxiv : the preprint server for health sciences · 2024Article
- Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.medRxiv : the preprint server for health sciences · 2023Article
- Non-Invasive Prenatal Testing for "Non-Medical" Traits: Ensuring Consistency in Ethical Decision-Making.The American journal of bioethics : AJOB · 2023Article
- Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives.Biomedicines · 2022Review
- A complex systems view on the current hypotheses of epilepsy pharmacoresistance.Epilepsia open · 2022Review
- Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.Nature communications · 2022Article
- Epilepsy and other seizure disorders in acute psychiatric inpatients.BMC psychiatry · 2021Article
- Transcriptome of the Krushinsky-Molodkina Audiogenic Rat Strain and Identification of Possible Audiogenic Epilepsy-Associated Genes.Frontiers in molecular neuroscience · 2021Article
- Polygenic risk heterogeneity among focal epilepsies.Epilepsia · 2020Article
- Neurological disorder-associated genetic variants in individuals with psychogenic nonepileptic seizures.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
Epilepsy is clinically heterogeneous, and neurological or psychiatric comorbidities are frequently observed in patients. It has not been tested whether common risk variants for generalized or focal epilepsy are enriched in people with other disorders or traits related to brain or cognitive function. Here, we perform two brain-focused phenome association studies of polygenic risk scores (PRS) for generalized epilepsy (GE-PRS) or focal epilepsy (FE-PRS) with all binary brain or cognitive function-related traits available for 334,310 European-ancestry individuals of the UK Biobank. Higher GE-PRS were associated with not having a college or university degree (P = 3.00x10-4), five neuroticism-related personality traits (P<2.51x10-4), and having ever smoked (P = 1.27x10-6). Higher FE-PRS were associated with several measures of low educational attainment (P<4.87x10-5), one neuroticism-related personality trait (P = 2.33x10-4), having ever smoked (P = 1.71x10-4), and having experienced events of anxiety or depression (P = 2.83x10-4). GE- and FE-PRS had the same direction of effect for each of the associated traits. Genetic factors associated with GE or FE showed similar patterns of correlation with genetic factors associated with cortical morphology in a subset of the UKB with 16,612 individuals and T1 magnetic resonance imaging data. In summary, our results suggest that genetic factors associated with epilepsies may confer risk for other neurological and psychiatric disorders in a population sample not enriched for epilepsy.
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