Observational studyPloS one2020
Validating the Chinese geriatric trigger tool and analyzing adverse drug event associated risk factors in elderly Chinese patients: A retrospective review.
Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Triggers for identifying anticoagulation-associated adverse drug events in hospitalized patients: a systematic review and meta-analysis.International journal of clinical pharmacy · 2025Pooled it
- Risk prediction models for adverse drug reactions and adverse drug events in older adults-a systematic review and meta-analysis.European journal of clinical pharmacology · 2025Pooled it
- Machine learning to predict adverse drug events based on electronic health records: a systematic review and meta-analysis.The Journal of international medical research · 2024Pooled it
- Adverse events identified by a trigger tool as indicators of patient safety and safety management in a medical department.Frontiers in public health · 2025Observational
- Application and evaluation of the global trigger tool approach to adverse drug event monitoring in the high-risk elderly inpatients with multiple chronic diseases.Frontiers in pharmacology · 2025Article
- Development of a warning model for drug-induced liver injury in the older patients.Frontiers in pharmacology · 2025Article
- Article
- The application of Global Trigger Tool in monitoring antineoplastic adverse drug events: a retrospective study.Frontiers in oncology · 2024Article
- Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method.Frontiers in pharmacology · 2024Article
- Predicting Hepatotoxicity Associated with Low-Dose Methotrexate Using Machine Learning.Journal of clinical medicine · 2023Article
- Article
- Predicting adverse drug events in older inpatients: a machine learning study.International journal of clinical pharmacy · 2022Article
- Chronic-pharma: New Platform for Chronic Patients Pharmacotherapy Optimization.Journal of medical systems · 2022Article
- Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study.Patient safety in surgery · 2022Article
- A Risk-Factor Model for Antineoplastic Drug-Induced Serious Adverse Events in Cancer Inpatients: A Retrospective Study Based on the Global Trigger Tool and Machine Learning.Frontiers in pharmacology · 2022Article
- Translation, Cross-Cultural Adaptation, and Measurement Properties of the Portuguese Version of the Global Trigger Tool for Adverse Events.Therapeutics and clinical risk management · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim was to evaluate the performance of the initial Chinese geriatric trigger tool to detect adverse drug events (ADEs) in Chinese older patients, to attempt to shorten this list for improving the efficiency of the trigger tool, and to study the incidence and characteristics of ADEs in this population.
methodsA sample of 25 cases was randomly selected per half a month from eligible patients who aged 60 years and older, hospitalized more than 24 hours, and discharged or died between January 1, 2015 and December 31, 2017 in West China hospital. A two-stage retrospective chart review of the included inpatients were conducted. ADEs were detected using a list of 42 triggers previously selected by an expert panel by means of a Delphi method. The number of triggers identified and ADEs detected were recorded and the positive predictive value (PPV) of each trigger was calculated to select the most efficient triggers. Several variables were recorded, including age, sex, number of diseases, length of hospital stay and so on, to analyze the risk factor of ADEs.
resultsAmong 1800 patients, 1646 positive triggers and 296 ADEs were detected in 234 (13.00%) patients. Older patients who were younger, had more medications, longer stays or more admission, and did not experience surgical operation more likely experienced ADEs. Triggers with PPV less than 5% were eliminated, which resulted in the upgraded version of Chinese geriatric trigger tool of 20 triggers with a PPV of 28.50%. This upgraded tool accounted for 99.66% of all ADEs detected.
conclusionsThe upgraded version of Chinese geriatric trigger tool was an efficient tool for identifying ADEs in Chinese older patients. Future, the trigger tool could be incorporated into routine screen systems to provide real-time identification of ADEs, thereby enabling timely clinical interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.