Evidence map›Paper›PMID 32343145›Full record

ArticleJournal of medicinal chemistry2020

Exploration of the Structural Space in 4(3

Yuanyuan Qian, Giuseppe Allegretta, Jeshina Janardhanan, Zhihong Peng, Kiran V Mahasenan, Elena Lastochkin, Melissa Malia N Gozun, Sara Tejera, Valerie A Schroeder, William R Wolter and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Unconventional Antibacterials and Adjuvants.Accounts of chemical research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yuanyuan QianDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Giuseppe AllegrettaDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Jeshina JanardhananDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Zhihong PengDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Kiran V MahasenanDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Elena LastochkinDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Melissa Malia N GozunDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Sara TejeraDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Valerie A SchroederDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
William R WolterFreimann Life Sciences Center, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Rhona FeltzerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-7695-7883
Mayland ChangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-4333-3775
University of Notre Dame · US

Funding

Inducible Antibiotic Resistance in Methicillin-Resistant Staphylococcus AureusR01AI104987 · NIAID · UNIVERSITY OF NOTRE DAME · PI Shahriar Mobashery · 2013 to 2026
$7.3M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
The quinazolinone class of antibacterial agentsR01AI116548 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F · 2015 to 2019
$3.0M
NIAID NIH HHS R01 AI104987NIAID NIH HHS R01 AI116548NIGMS NIH HHS T32 GM075762
6 · The paper itself

Abstract

We report herein the syntheses of 79 derivatives of the 4(3

Indexed as

AnimalsAnti-Bacterial AgentsFemaleMiceMice, Inbred ICRMicrobial Sensitivity TestsNeutropeniaQuinazolinonesStaphylococcus aureusStructure-Activity Relationship4-hydroxyquinazolineAnti-Bacterial AgentsQuinazolinones

Identifiers

PMID32343145
PMCPMC7720656
OpenAlexW3017805136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.