Evidence map›Paper›PMID 32343001›Full record

Trial reportAlimentary pharmacology & therapeutics2020

Randomised clinical trial: the effectiveness of Gaviscon Advance vs non-alginate antacid in suppression of acid pocket and post-prandial reflux in obese individuals after late-night supper.

Mohd Adli Deraman, Muhammad Ilham Abdul Hafidz, Rona Marie Lawenko, Zheng Feei Ma, Mung Seong Wong, Cathal Coyle, Yeong Yeh Lee

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alimentary pharmacology & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03516188 (Open-label Antacid-controlled Randomized Study on Effectiveness of Alginate-antacid Preparation), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03516188 phase2 / phase3completednot on this map

Open-label Antacid-controlled Randomized Study on Effectiveness of Alginate-antacid Preparation (Gaviscon-Advance®) in Suppression of Post-supper Acid-pocket, Night-time Acid-reflux and Symptoms in Obese Participants

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2016 to 2017Enrolled24ConditionsGastroesophageal Reflux Disease, Acid Reflux, ObesityArmsAlginate-antacid group, Non antacid alginate group
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 5 countries.

Mohd Adli DeramanSchool of Medical Sciences, Universiti Sains Malaysia, Kota Bahru, Malaysia.
Muhammad Ilham Abdul HafidzFaculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia.
Rona Marie LawenkoDe La Salle Health Sciences Institute, Dasmarinas, Philippines.
Zheng Feei MaSchool of Medical Sciences, Universiti Sains Malaysia, Kota Bahru, Malaysia.ORCID 0000-0002-7276-2229
Mung Seong WongSchool of Medical Sciences, Universiti Sains Malaysia, Kota Bahru, Malaysia.
Cathal CoyleReckitt Benckiser, Slough, UK.ORCID 0000-0003-3190-8460
Yeong Yeh LeeSchool of Medical Sciences, Universiti Sains Malaysia, Kota Bahru, Malaysia.ORCID 0000-0002-6486-7717
Universiti Sains Malaysia · MYDe La Salle University – Dasmariñas · PHHospital Sungai Buloh · MYReckitt Benckiser (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLate-night supper increases the risk of postprandial reflux from the acid pocket especially in obesity. An alginate-based, raft-forming medication may be useful for obese patients with GERD.

aimsTo compare the efficacy of Gaviscon Advance (Reckitt Benckiser, UK) and a non-alginate antacid in post-supper suppression of the acid pocket and post-prandial reflux among obese participants.

methodsParticipants underwent 48 h wireless and probe-based pH-metry recording of the acid pocket and lower oesophagus, respectively, and were randomised to single post-supper (10 pm) dose of either Gaviscon Advance or a non-alginate antacid on the second night. Primary outcomes were suppression of median pH of acid pocket and lower oesophagus, measured every 10-minutes post-supper for 1 h. Secondary outcomes were suppression of % time pH < 4 at lower oesophagus and improvement in frequency and visual analogue score (VAS) of regurgitation.

resultsOf the 81 screened participants, 55 were excluded and 26 (mean age 33.5 years, males 77.8% and BMI 32.8 kg/m

conclusionsAmong obese individuals, Gaviscon Advance was superior to a non-alginate antacid in post-supper suppression of the acid pocket. (Clinical trial registration unique identifier: NCT03516188).

Indexed as

MealsAdultAlginatesAluminum HydroxideAntacidsAnti-Ulcer AgentsDrug CombinationsFemaleGastric AcidGastroesophageal RefluxHumansHydrogen-Ion ConcentrationMalaysiaMaleMiddle AgedObesityalginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combinationAlginatesAluminum HydroxideAntacidsAnti-Ulcer AgentsDrug CombinationsSilicic AcidSodium Bicarbonate

Identifiers

PMID32343001
PMCPMC7318318
OpenAlexW3020442453

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.