Evidence map›Paper›PMID 32342872›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2020

A rapid review of evidence and recommendations from the SIOPE radiation oncology working group to help mitigate for reduced paediatric radiotherapy capacity during the COVID-19 pandemic or other crises.

Geert O Janssens, Henry C Mandeville, Beate Timmermann, John H Maduro, Claire Alapetite, Laetitia Padovani, Gail Horan, Yasmin Lassen-Ramshad, Karin Dieckmann, Christian Ruebe and 4 more

Abstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Nursing Care for Metastatic Bone Cancer: Trends for the Future.International journal of environmental research and public health · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Radiotherapy during the COVID-19: a review about management and treatment strategies.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Article
  9. Observational
  10. Article
  11. Article
  12. The Response of the UK Clinical Oncology Community to the COVID-19 Pandemic.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2020
    Article
  13. Article
  14. Evolution of clinical radiotherapy physics practice under COVID-19 constraints.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Geert O JanssensDepartment of Radiation Oncology, University Medical Centre Utrecht, The Netherlands; Princess Maxima Centre for Paediatric Oncology, Utrecht, The Netherlands.
Henry C MandevilleDepartment of Radiotherapy, The Royal Marsden Hospital, Sutton, United Kingdom; The Institute of Cancer Research, Sutton, United Kingdom.
Beate TimmermannDepartment of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ) and German Cancer Consortium (DKTK), Germany.
John H MaduroPrincess Maxima Centre for Paediatric Oncology, Utrecht, The Netherlands; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
Claire AlapetiteDepartment of Radiation Oncology & Proton Center, Institut Curie, France.
Laetitia PadovaniAix-Marseille University, Oncology Radiotherapy Department, CRCM Inserm, UMR1068, CNRS UMR7258, AMU UM105, Genome Instability and Carcinogenesis, APHM, France.
Gail HoranDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, United Kingdom.
Yasmin Lassen-RamshadDanish Centre for Particle Therapy, Aarhus, Denmark.
Karin DieckmannDepartment of Radiotherapy Medical University Vienna, Austria.
Christian RuebeStrahlentherapie und Radioonkologie, Universitätsklinikum des Saarlandes, Homburg, Germany.
Nicky ThorpDepartment of Radiotherapy, The Clatterbridge Cancer Centre, Wirral, United Kingdom; The Proton Beam Therapy Centre, The Christie Hospital, Manchester, United Kingdom.
Lorenza GandolaPediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Thankamma AjithkumarDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, United Kingdom. Electronic address: thankamma.ajithkumar@addenbrookes.nhs.uk.
Tom BoterbergDepartment of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo derive evidence-based recommendations for the optimal utilisation of resources during unexpected shortage of radiotherapy capacity. METHODS AND MATERIALS: We have undertaken a rapid review of published literature on the role of radiotherapy in the multimodality treatment of paediatric cancers governing the European practise of paediatric radiotherapy. The derived data has been discussed with expert paediatric radiation oncologists to derive a hierarchy of recommendations.

resultsThe general recommendations to mitigate the potential detriment of an unexpected shortage of radiotherapy facilities include: (1) maintain current standards of care as long as possible (2) refer to another specialist paediatric radiotherapy department with similar level of expertise (3) prioritise use of existing radiotherapy resources to treat patients with tumours where radiotherapy has the most effect on clinical outcome (4) use chemotherapy to defer the start of radiotherapy where timing of radiotherapy is not expected to be detrimental (5) active surveillance for low-grade tumours if appropriate and (6) consider iso-effective hypofractionated radiotherapy regimens only for selected patients with predicted poor prognosis. The effectiveness of radiotherapy and recommendations for prioritisation of its use for common and challenging paediatric tumours are discussed.

conclusionThis review provides evidence-based treatment recommendations during unexpected shortage of paediatric radiotherapy facilities. It has wider applications for the optimal utilisation of facilities, to improve clinical outcome in low- and middle-income countries, where limited resources continue to be a challenge.

Indexed as

BetacoronavirusChildCombined Modality TherapyCoronavirus InfectionsCOVID-19Guidelines as TopicHumansNeoplasmsPandemicsPneumonia, ViralRadiation OncologySARS-CoV-2CoronavirusCOVID-19PaediatricRadiotherapyResourcesTreatment

Identifiers

PMID32342872
PMCPMC7184972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.