Evidence map›Paper›PMID 32342871›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2020

Is low dose radiation therapy a potential treatment for COVID-19 pneumonia?

Charles Kirkby, Marc Mackenzie

4 registry-linked trialsAbstract readEditorialComment
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04380818 naunknown statusnot on this map

Low Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19: Multi-central Prospective Study

TypeinterventionalSponsorGrupo de Investigación Clínica en Oncología RadioterapiaRan2020 to 2021Enrolled106ConditionsPneumonia, ViralArmsLow-dose radiotherapy, Hydroxychloroquine Sulfate, Ritonavir/lopinavir, Tocilizumab Injection [Actemra], Azithromycin
NCT04390412 phase1 / phase2unknown statusnot on this map

Assessment of Adding Low Dose Pulmonary Radiotherapy to the National Protocol of COVID-19 Management: A Pilot Trial

TypeinterventionalSponsorShahid Beheshti University of Medical SciencesRan2020 to 2020Enrolled5ConditionsCOVID, SARS (Severe Acute Respiratory Syndrome)ArmsLow Dose Radiotherapy
NCT04394182 nasuspendednot on this map

Low Doses of Lung Radiation Therapy in Cases of COVID-19 Pneumonia: Prospective Multicentric Study in Radiation Oncology Centers

TypeinterventionalSponsorFundacion GenesisCareRan2020 to 2022Enrolled15ConditionsPneumonia, Viral, Cytokine StormArmsUltra-Low-dose radiotherapy, ventilatory support with oxygen therapy, Lopinavir/ritonavir, Hydroxychloroquine, Azithromycin
NCT04394793 naunknown statusnot on this map

Low Dose Radiation Therapy for Covid-19 Pneumonia: A Pilot Study

TypeinterventionalSponsorAll India Institute of Medical SciencesRan2020 to 2020Enrolled10ConditionsCOVID-19, PneumoniaArmsLow dose radiation therapy
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a single institution report of two cases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Trial
  3. Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results.International journal of radiation oncology, biology, physics · 2020
    Trial
  4. Article
  5. Radiotherapy for non-cancer diseases: benefits and long-term risks.International journal of radiation biology · 2024
    Review
  6. Review
  7. Article
  8. Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2022
    Article
  9. Review
  10. Article
  11. COVID-19 and low-dose radiation therapy.Radiation medicine and protection · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. [Low dose radiotherapy for COVID-19 pneumopathy: Biological rationale and literature review].Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2021
    Review
  16. Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Final Results of a Pilot Study.International journal of radiation oncology, biology, physics · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Low-dose radiation therapy: could it be a game-changer for COVID-19?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Charles KirkbyDepartment of Medical Physics, Jack Ady Cancer Centre, Lethbridge, Canada; Department of Oncology, University of Calgary, Canada; Department of Physics and Astronomy, University of Calgary, Canada. Electronic address: charles.kirkby@ahs.ca.
Marc MackenzieDepartment of Oncology, University of Alberta, Edmonton, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BetacoronavirusCoronavirus InfectionsPneumonia, ViralCOVID-19HumansPandemicsSARS-CoV-2

Identifiers

PMID32342871
PMCPMC7194710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.