Evidence map›Paper›PMID 32342848›Full record

Trial reportThe American journal of tropical medicine and hygiene2020

Safety and Immunogenicity of an AS03

Leyi Lin, Kirsten E Lyke, Michael Koren, Richard G Jarman, Kenneth H Eckels, Edith Lepine, Monica A McArthur, Jeffrey R Currier, Heather Friberg, Philippe Moris and 6 more

Open access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Dengue Vaccines.Current topics in microbiology and immunology · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Leyi Lin1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Kirsten E Lyke2Center for Vaccine Development and Global Health (CVD), University of Maryland, Baltimore, Maryland.
Michael Koren1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Richard G Jarman1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Kenneth H Eckels1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Edith Lepine3GSK, Rockville, Maryland.
Monica A McArthur2Center for Vaccine Development and Global Health (CVD), University of Maryland, Baltimore, Maryland.
Jeffrey R Currier1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Heather Friberg1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Philippe Moris4GSK, Rixensart, Belgium.
Paul B Keiser1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Rafael De La Barrera1Walter Reed Army Institute of Research, Silver Spring, Maryland.
David W Vaughn3GSK, Rockville, Maryland.
Robert M Paris3GSK, Rockville, Maryland.
Stephen J Thomas1Walter Reed Army Institute of Research, Silver Spring, Maryland.
Alexander C Schmidt3GSK, Rockville, Maryland.
Walter Reed Army Institute of Research · USGlaxoSmithKline (United States) · USUniversity of Maryland, Baltimore · USGlaxoSmithKline (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue disease and its causative agents, the dengue viruses (DENV-1-4), cause high morbidity in tropical and subtropical regions. We evaluated three dosing regimens of the investigational tetravalent AS03

Indexed as

AdultAntibodies, NeutralizingAntibodies, ViralDengueDengue VaccinesDengue VirusFemaleHealthy VolunteersHumansImmunogenicity, VaccineMaleMiddle AgedPatient SafetyVaccinationVaccines, AttenuatedVaccines, SubunitAntibodies, NeutralizingAntibodies, ViralDengue VaccinesVaccines, AttenuatedVaccines, Subunit

Identifiers

PMID32342848
PMCPMC7356407
OpenAlexW3018899559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.