Evidence map›Paper›PMID 32342847›Full record

ArticleThe American journal of tropical medicine and hygiene2020

Central Nervous System Virus Infection in African Children with Cerebral Malaria.

Douglas G Postels, Lawrence Osei-Tutu, Karl B Seydel, Qian Xu, Chenxi Li, Terrie E Taylor, Chandy C John, Macpherson Mallewa, Tom Solomon, Tsiri Agbenyega and 8 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Pediatric Cerebral Malaria.Current tropical medicine reports · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 5 countries.

Douglas G Postels1Department of Neurology, Children's National Medical Center, George Washington University, Washington, District of Columbia.
Lawrence Osei-Tutu2Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Karl B Seydel3Department of Osteopathic Medical Specialties, Michigan State University, East Lansing, Michigan.
Qian Xu5Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan.
Chenxi Li5Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan.
Terrie E Taylor3Department of Osteopathic Medical Specialties, Michigan State University, East Lansing, Michigan.
Chandy C John6Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
Macpherson Mallewa7University of Malawi College of Medicine, Blantyre, Malawi.
Tom Solomon8Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Tsiri Agbenyega2Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Daniel Ansong2Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Robert O Opoka9Department of Paediatrics and Child Health, Makerere University School of Medicine, Kampala, Uganda.
Lillian M Khan10Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California.
Prashanth S Ramachandran11Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, California.
Kristoffer E Leon12UCSF School of Medicine, University of California San Francisco, San Francisco, California.
Joseph L DeRisi10Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California.
Charles Langelier14Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California.
Michael R Wilson11Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USKwame Nkrumah University of Science and Technology · GHMichigan State University · USUniversity of Malawi · MWChildren's National · USIndiana University School of MedicineMakerere University · UGUniversity of Liverpool · GB

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
DON in Pediatric Cerebral Malaria: A Phase I / II Dose-Escalation Safety StudyU01AI155300 · NIAID · CHILDREN'S RESEARCH INSTITUTE · PI POSTELS, DOUGLAS · 2021 to 2025
$5.6M
Next-Generation Diagnostics for Acute EncephalitisK08NS096117 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILSON, MICHAEL R · 2017 to 2021
$999k
Viral Co-Infections in Cerebral Malaria: Preparing for Clinical TrialsR21HD078471 · NICHD · MICHIGAN STATE UNIVERSITY · PI POSTELS, DOUGLAS · 2014 to 2015
$286k
Department of Health 12/205/28Department of Health IS-HPU-1112-10117Department of Health RP-PG-0108-10048NIAID NIH HHS U01 AI155300NICHD NIH HHS R21 HD078471NIGMS NIH HHS T32 GM007618NINDS NIH HHS K08 NS096117NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

We aimed to identify the contribution of central nervous system (CNS) viral coinfection to illness in African children with retinopathy-negative or retinopathy-positive cerebral malaria (CM). We collected cerebrospinal fluid (CSF) from 272 children with retinopathy-negative or retinopathy-positive CM and selected CSF from 111 of these children (38 retinopathy positive, 71 retinopathy negative, 2 retinopathy unknown) for analysis by metagenomic next-generation sequencing. We found CSF viral coinfections in 7/38 (18.4%) retinopathy-positive children and in 18/71 (25.4%) retinopathy-negative children. Excluding HIV-1, human herpesviruses (HHV) represented 61% of viruses identified. Excluding HIV-1, CNS viral coinfection was equally likely in children who were retinopathy positive and retinopathy negative (

Indexed as

Central Nervous System Viral DiseasesChildCoinfectionFemaleGhanaHerpesviridae InfectionsHigh-Throughput Nucleotide SequencingHumansMalaria, CerebralMalawiMaleRetinal DiseasesUganda

Identifiers

PMID32342847
PMCPMC7356427
OpenAlexW3020143400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.