Evidence map›Paper›PMID 32342775›Full record

ArticleThe Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics2020

Whether to Waive Parental Permission in HIV Prevention Research Among Adolescents: Ethical and Legal Considerations.

Laurie J Bauman, Claude Ann Mellins, Robert Klitzman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Lessons Learned in Engaging Adolescents and Young Adults to End the US HIV Epidemic.Journal of acquired immune deficiency syndromes (1999) · 2025
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  9. A Position Statement on Mpox as a Sexually Transmitted Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Laurie J BaumanLaurie J. Bauman, Ph.D., is Professor of Pediatrics and Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine, where she also serves as Director of the Preventive Intervention Research Center and of the Behavioral Science Core of the Einstein-Rockefeller-CUNY Center for AIDS Research. She is also Director of the Bio-Behavioral Core of the HIV Center for Clinical and Behavioral Studies. Her research addresses HIV prevention among adolescents, including behavioral interventions and adoption of PrEP. Claude Ann Mellins, Ph.D., is a clinical psychologist and Professor of Medical Psychology in Psychiatry and Sociomedical Sciences at the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University. She is the co-director of the HIV Center with 28 years of clinical and research experience working globally with youth and families affected by HIV. Robert Klitzman, M.D., is a professor of psychiatry at the Vagelos College of Physicians and Surgeons and the Mailman School of Public Health, and the Director of the online and in-person Bioethics Masters and Certificate Programs at Columbia University. He has published over 150 scientific journal articles and nine books on ethical issues concerning HIV, genetics, research, and other areas.
Claude Ann MellinsLaurie J. Bauman, Ph.D., is Professor of Pediatrics and Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine, where she also serves as Director of the Preventive Intervention Research Center and of the Behavioral Science Core of the Einstein-Rockefeller-CUNY Center for AIDS Research. She is also Director of the Bio-Behavioral Core of the HIV Center for Clinical and Behavioral Studies. Her research addresses HIV prevention among adolescents, including behavioral interventions and adoption of PrEP. Claude Ann Mellins, Ph.D., is a clinical psychologist and Professor of Medical Psychology in Psychiatry and Sociomedical Sciences at the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University. She is the co-director of the HIV Center with 28 years of clinical and research experience working globally with youth and families affected by HIV. Robert Klitzman, M.D., is a professor of psychiatry at the Vagelos College of Physicians and Surgeons and the Mailman School of Public Health, and the Director of the online and in-person Bioethics Masters and Certificate Programs at Columbia University. He has published over 150 scientific journal articles and nine books on ethical issues concerning HIV, genetics, research, and other areas.
Robert KlitzmanLaurie J. Bauman, Ph.D., is Professor of Pediatrics and Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine, where she also serves as Director of the Preventive Intervention Research Center and of the Behavioral Science Core of the Einstein-Rockefeller-CUNY Center for AIDS Research. She is also Director of the Bio-Behavioral Core of the HIV Center for Clinical and Behavioral Studies. Her research addresses HIV prevention among adolescents, including behavioral interventions and adoption of PrEP. Claude Ann Mellins, Ph.D., is a clinical psychologist and Professor of Medical Psychology in Psychiatry and Sociomedical Sciences at the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University. She is the co-director of the HIV Center with 28 years of clinical and research experience working globally with youth and families affected by HIV. Robert Klitzman, M.D., is a professor of psychiatry at the Vagelos College of Physicians and Surgeons and the Mailman School of Public Health, and the Director of the online and in-person Bioethics Masters and Certificate Programs at Columbia University. He has published over 150 scientific journal articles and nine books on ethical issues concerning HIV, genetics, research, and other areas.
Behavioral Tech · USYeshiva University · US

Funding

The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Claude Ann Mellins · 2003 to 2026
$48.2M
NIMH NIH HHS P30 MH043520
6 · The paper itself

Abstract

Critical ethical questions arise concerning whether studies among adolescents of new behavioral and biomedical HIV preventive interventions such as Pre-Exposure Prophylaxis (PrEP) should obtain parental permission. This paper examines the relevant regulations and ethical guidance concerning waivers of parental permission, and arguments for and against such waivers. Opponents of such waivers may argue that adolescent decision-making is "too immature" and that parents always have rights to decide how to protect their children. Yet requiring parental permission may put adolescents at risk, and/or limit adolescent participation, jeopardizing study findings' validity. This paper presents recommendations on when researchers and Institutional Review Boards (IRB) should waive parental permission, and what special protections should be adopted for adolescents who consent for themselves, e.g., assuring adolescent privacy and confidentiality, screening for capacity to consent, and identifying adolescents who are at elevated risk from study participation. We also present a series of specific areas for future research to design tools to help make these assessments, and to inform researcher and IRB decisions. These recommendations can help ensure that research is conducted that can aid adolescents at risk for HIV, while minimizing risks and protecting these individuals' rights as much as possible.

Indexed as

Research SubjectsAdolescentDecision MakingEthics Committees, ResearchHIV InfectionsHumansInformed Consent By MinorsParental ConsentPre-Exposure ProphylaxisResearch PersonnelUnited States

Identifiers

PMID32342775
PMCPMC8367279
OpenAlexW3022372092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.