ArticleBrain and behavior2020
Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- Multivariate sharp-wave ripples in schizophrenia during awake state.Psychiatry and clinical neurosciences · 2024Article
- Transcorneal Electrical Stimulation Induces Long-Lasting Enhancement of Brain Functional and Directional Connectivity in Retinal Degeneration Mice.Frontiers in cellular neuroscience · 2022Article
- Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.Brain and behavior · 2020Article
- Prospects for Future Methodological Development and Application of Magnetoencephalography Devices in Psychiatry.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
objectiveThe ability to integrate audiovisual information matures late in adolescents, but its neuronal mechanism is still unknown. Recent studies showed that phase-amplitude coupling (PAC) of neuronal oscillations, which is defined as the modulation of high-frequency amplitude by low-frequency phase, is associated with audiovisual integration in adults. Thus, we investigated how PAC develops in adolescents and whether it is related to the functional maturation of audiovisual integration. In particular, we focused on the timing of PAC (or the coupling phase), which is defined as the low-frequency phase with maximum high-frequency amplitude.
methodsUsing magnetoencephalography (MEG) on 15 adults and 14 adolescents while they performed an audiovisual speech integration task, we examined PAC in association cortexes with a trial-by-trial analysis.
resultsWhereas delta-beta coupling was consistently observed in both adults and adolescents, we found that the timing of delta-beta PAC was delayed by 20-40 milliseconds in adolescents compared with adults. In addition, a logistic regression analysis revealed that the task performance improves as the timing of delta-beta PAC in the right temporal pole (TP) got closer to the trough position (180 degrees).
conclusionThese results suggest that the timing of PAC is essential for binding audiovisual information and underlies the developmental process in adolescents.
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