Evidence map›Paper›PMID 32342627›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Kidney nonprocurement in solid organ donors in the United States.

Kathleen Yu, Kristen King, Syed A Husain, Geoffrey K Dube, Jacob S Stevens, Lloyd E Ratner, Matthew Cooper, Chirag R Parikh, Sumit Mohan

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Kidney utilization in the Netherlands - do we optimally use our donor organs?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Review
  8. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Article
  9. Early Effect of the Circular Model of Kidney Allocation in the United States.Journal of the American Society of Nephrology : JASN · 2023
    Article
  10. Article
  11. Article
  12. Examining utilization of kidneys as a function of procurement performance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Review
  13. Association of transplant center market concentration and local organ availability with deceased donor kidney utilization.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  14. Deceased donor kidneys allocated out of sequence by organ procurement organizations.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kathleen YuDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0001-5015-4110
Kristen KingDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.
Syed A HusainDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-1823-0117
Geoffrey K DubeDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0003-0206-5652
Jacob S StevensDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.
Lloyd E RatnerDepartment of Surgery, Division of Transplantation, Columbia University Medical Center, New York, New York, USA.
Matthew CooperMedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.
Chirag R ParikhDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9051-7385
Sumit MohanDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-5305-9685
Columbia University Irving Medical Center · USGeorgetown University · USJohns Hopkins University · US

Funding

Institutional Career Development CoreKL2TR001874 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GENKINGER, JEANINE M., SHIMBO, DAICHI · 2016 to 2025
$13.6M
Novel Kidney Injury Tools in Deceased Organ Donation to Predict Graft OutcomesR01DK093770 · NIDDK · YALE UNIVERSITY · PI Chirag R Parikh · 2012 to 2026
$9.5M
5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116066 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sumit Mohan, Deirdre Sawinski · 2017 to 2026
$2.5M
Identifying and exploring solutions to the ethical challenges of ApoL1 testing of donors with recent African ancestry through mixed methods research with stakeholdersR01MD014161 · NIMHD · WASHINGTON UNIVERSITY · PI DUBOIS, JAMES M, MOHAN, SUMIT · 2019 to 2021
$1.2M
Increasing Minority Population Awareness through Community Teaching for Improved Organ Donation (IMPACT for Improved Organ Donation)R01DK114893 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHAN, SUMIT · 2017 to 2021
$1.2M
HRSA HHS 234-2005-370011CNational Institutes of Health/National Institutes of Diabetes and Digestive and Kidney Diseases R01 DK93770NCATS NIH HHS KL2 TR001874NIDDK NIH HHS R01 DK093770NIDDK NIH HHS R01 DK114893NIDDK NIH HHS U01 DK116066NIMHD NIH HHS R01 MD014161
6 · The paper itself

Abstract

There are limited data on the nonprocurement of kidneys from solid organ donors. Analysis of Standard Transplant Analysis and Research files was undertaken on all deceased donors in the United States with at least 1 solid organ recovered. From 2000 to 2018, 21 731 deceased donor kidneys (averaging 1144 kidneys per year) were not procured. No kidneys were procured from 8% of liver donors, 3% of heart donors, and 3% of lung donors. Compared to donors with all kidneys procured, those with none procured were older and more likely obese, black, hypertensive, diabetic, hepatitis C positive, smokers, Public Health Service - Increased Risk designated, deceased after cardiac death, or deceased after cerebrovascular accident. Although these donors had lower quality kidneys (median Kidney Donor Risk Index (interquartile range) 1.9 (1.0) vs 1.2 (0.7)), there was substantial overlap in quality between nonprocured and procured kidneys. Nearly one third of nonprocurements were attributed to donor history. Donors with elevated terminal creatinine likely resulting from acute kidney injury (AKI) had higher odds of kidney nonprocurement. Nonprocurement odds varied widely across Organ Procurement and Transplantation Network regions, with a positive correlation between donor kidney nonprocurements and kidney discards at the donation service area level. These findings suggest current discard rates underestimate the underutilization of deceased donor kidneys and more research is needed to optimize safe procurement and utilization of kidneys from donors with AKI.

Indexed as

Kidney TransplantationTissue and Organ ProcurementDonor SelectionHumansKidneyRisk FactorsTissue DonorsUnited Statesclinical research/practicedonors and donation: deceasedhealth services and outcomes researchkidney transplantation/nephrologyorgan acceptanceorgan procurementorgan procurement and allocationorgan procurement organizationUnited Network for Organ Sharing (UNOS)

Identifiers

PMID32342627
PMCPMC8448558
OpenAlexW3019858486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.