ArticleJournal of neuro-oncology2020
Clinical characteristics and prognostic factors of adult patients with pilocytic astrocytoma.
Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Clinical potential of [European journal of nuclear medicine and molecular imaging · 2026Article
- Network-based exploration of 4-(phenylsulfonyl)morpholine molecules for metastatic triple-negative breast cancer suppression.PLoS computational biology · 2026Article
- Fourth ventricular pilocytic astrocytoma mimicking an arachnoid cyst: A case report and review of literature.Surgical neurology international · 2026Article
- Unpredictable Evolution of Pilocytic Astrocytoma in Adults: A Case Series and Diagnostic Challenges.The American journal of case reports · 2025Article
- Pilocytic Astrocytoma: An institutional perspective over the last decade.Pakistan journal of medical sciences · 2025Article
- Clinical and genomic factors differ in pediatric and adult pilocytic astrocytoma: a single-center experience with over 350 patients.Journal of neuro-oncology · 2025Article
- Adult pilocytic astrocytomas: challenging the benign paradigm with surgical risks, recurrence dynamics, and molecular insights.Neurosurgical review · 2025Article
- Pilocytic astrocytoma: A rare case report.Radiology case reports · 2025Article
- Article
- Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis.Brain tumor pathology · 2025Article
- Hypothalamic Hemangioma-like Pilocytic Astrocytoma in an Adult Patient: A Systematic Review with a Focus on Differential Diagnosis and Neurological Presentation.Journal of clinical medicine · 2024Review
- Magnetic resonance imaging characteristics of pediatric pilocytic astrocytoma.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Postoperative Communicating Hydrocephalus Following Grade 2/3 Glioma Resection: Incidence, Timing and Risk Factors.Cancers · 2023Article
- Comparison of the clinical features and treatment outcomes of pilocytic astrocytoma in pediatric and adult patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Clinical, radiological and pathological features of temporomesial tumors in the adult. A single center experience from 15 years.Frontiers in oncology · 2023Article
- The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology.Journal of neuro-oncology · 2022Article
- Insight about the characteristics and surgical resectability of adult pilocytic astrocytoma: tertiary center experience.CNS oncology · 2022Article
- Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature.Journal of neurology · 2022Review
- Fluorescein-guided surgery for the resection of pilocytic astrocytomas: A multicentric retrospective study.Frontiers in oncology · 2022Article
- High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity.Journal of neuro-oncology · 2021Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionPilocytic astrocytoma (PA) is the most common primary brain neoplasm in children and treated in curative intent with gross total resection (GTR). However, PA is rare in adults, resulting in limited knowledge on the natural clinical course. This study aimed to describe the clinical course and identify prognostic factors of adult patients with PA.
methods46 patients ≥ 18 years at diagnosis of PA and neurosurgical resection or biopsy between 2000 and 2018 were identified from the Neuro-Biobank of the Medical University of Vienna. In two cases with differing histopathological diagnosis at recurrence, DNA methylation analysis was performed using Illumina Infinium HumanMethylation850 BeadChip (850 k) arrays and the Molecular Neuropathology classifier. Clinico-pathological features were correlated with patient outcomes.
resultsMedian age at diagnosis was 32.5 years (range: 19-75) and median Ki67 proliferation index was 2.8% (0.5-13.4%). Tumor location significantly correlated with resectability (p < 0.001). Tumor progression or recurrence was observed in 9/46 (19.6%) patients after a median follow up time of 53.0 months (range 0.5-300). 5-year overall and progression-free survival rates were 85.3% and 70.0%, respectively. 2/9 (22.2%) patients presented with histological changes in the recurrent tumor specimen. In detail, methylation classification redefined the histological diagnosis to anaplastic astrocytoma with piloid features and glioma in one patient, each. Age > 40 and higher body mass index (BMI) were associated with impaired progression-free and overall survival (p < 0.05).
conclusionsTumor recurrence or progression in adult PA patients was higher than the one reported in pediatric patients. Higher age and BMI were associated with impaired prognosis.
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