Evidence map›Paper›PMID 32342313›Full record

ArticleDoklady. Biochemistry and biophysics2020

Stabilization of Modular Nanotransporters by Embedding Hemin in Them in a New Strain with Heme Receptor Expression.

Yu V Khramtsov, A V Ulasov, A A Rosenkranz, G P Georgiev, A S Sobolev

Abstract read
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Article in Doklady. Biochemistry and biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu V KhramtsovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
A V UlasovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
A A RosenkranzInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
G P GeorgievInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
A S SobolevInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. sobolev@igb.ac.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It was found that the use of a new strain-producer Escherichia coli, expressing the heme receptor ChuA, enables obtaining a hemin-containing modular nanotransporter (MNT) for drug delivery into the nuclei of target cells. The hemin-containing MNT becomes stabilized, which leads to an increase in its thermal stability and prevents aggregation of this protein.

Indexed as

Antineoplastic AgentsBacterial Outer Membrane ProteinsChromatography, GelDrug CarriersElectronsEscherichia coliEscherichia coli ProteinsHemeHeminLigandsLysosomesNanotechnologyPlasmidsProtein BindingReceptors, Cell SurfaceTemperatureAntineoplastic AgentsBacterial Outer Membrane ProteinsChuA protein, E coliDrug CarriersEscherichia coli ProteinsHemeheme receptorHeminLigandsReceptors, Cell Surfaceaggregatesheme embeddingmodular nanotransportersthermal stability

Identifiers

PMID32342313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.