Evidence map›Paper›PMID 32342266›Full record

Trial reportObesity surgery2020

Application of Vitamin E Acetate on Staple Lines and Anastomoses of Roux-en-Y Gastric Bypass: Impact on Postoperative Pain and Acute Phase Reactants.

Jaime Ruiz-Tovar, Alejandro Garcia, Carlos Ferrigni, Manuel Duran

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03765827 phase3completednot on this map

Effect of the Application of Vitamin E Ointment, Over Staple Lines and Anastomosis in Roux-en-Y Gastric Bypass, on Postoperative Pain

TypeinterventionalSponsorHospital General Universitario ElcheRan2018 to 2019Enrolled140ConditionsPostoperative PainArmsVitamine E Acetate, No application of vitamin E acetate
NCT07246785 phase4terminatednot on this mapstarted 2025, after this paper: background citation

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled13ConditionsLaparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous AnalgesiaArmsHigh-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon, Morphine
NCT07525986 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Tria

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled140ConditionsLaparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous AnalgesiaArmsHigh-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon, Morphine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jaime Ruiz-TovarBariatric and Metabolic Surgery Unit, Rey Juan Carlos University Hospital, Gladiolo, s/n, 28933, Madrid, Spain. jruiztovar@gmail.com.ORCID http://orcid.org/0000-0002-8505-2605
Alejandro GarciaBariatric and Metabolic Surgery Unit, Rey Juan Carlos University Hospital, Gladiolo, s/n, 28933, Madrid, Spain.
Carlos FerrigniBariatric and Metabolic Surgery Unit, Rey Juan Carlos University Hospital, Gladiolo, s/n, 28933, Madrid, Spain.
Manuel DuranBariatric and Metabolic Surgery Unit, Rey Juan Carlos University Hospital, Gladiolo, s/n, 28933, Madrid, Spain.
Hospital Universitario Rey Juan Carlos · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative pain after laparoscopic surgery has 3 components: parietal, visceral, and associated with pneumoperitoneum. Visceral pain accounts for around 30% of the total pain and is less amenable to be controlled by multimodal analgesia. The topical application of vitamin E ointment has demonstrated an anti-inflammatory effect in the local inflammatory response against surgical aggression. Vitamin E has been also associated with a reduction in postoperative pain of skin wounds. The aim of this study was to evaluate the effect of the topical application of vitamin E acetate on staple lines and anastomoses of Roux-en-Y gastric bypass, as part of a multimodal analgesia scheme within an Enhanced Recovery After Surgery (ERAS) program.

methodsA prospective randomized clinical trial was performed. Patients were divided into 2 groups: patients receiving a topical application of vitamin E on staple lines and anastomoses (G1) and patients not receiving it (G2). The primary endpoint was postoperative pain, as measured by VAS 24 h after surgery. Secondary outcomes include morphine rescue needs, acute phase reactants 24 h after surgery, and hospital stay.

resultsOne hundred forty patients were included, 70 in each group. Postoperative pain was 10 mm in G1 and 21.8 mm in G2 (p < 0.001). Morphine needs within the first 24 h were 2.9% in G1 and 13.2% in G2 (p = 0.026). C-reactive protein levels were significantly lower in G1 (8.7 mg/dL vs 11.9; p = 0.016). Mean hospital stay was 2.1 days in G1 and 2.9 in G2 (p = 0.019).

conclusionTopical application of vitamin E reduces postoperative pain and acute phase reactants, allowing an earlier discharge.

trial registrationNCT03765827, https://www.clinicaltrials.gov.

Indexed as

Gastric BypassLaparoscopyObesity, MorbidAcetatesAcute-Phase ProteinsHumansPostoperative PainProspective StudiesVitamin EAcetatesAcute-Phase ProteinsVitamin EAnastomosisStaple linesVisceral painVitamin E

Identifiers

PMID32342266
OpenAlexW3019495348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.