ArticleWorld journal of microbiology & biotechnology2020
Effect of curcumin on the expression of ahyI/R quorum sensing genes and some associated phenotypes in pathogenic Aeromonas hydrophila fish isolates.
Article in World journal of microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular Insight into the Inhibition ofACS omega · 2026Article
- Natural product-based inhibitors of quorum sensing: A novel approach to combat antibiotic resistance.Biochemistry and biophysics reports · 2025Review
- Article
- Saponins from sea cucumber disrupt Aeromonas hydrophila quorum sensing to mitigate pathogenicity.AMB Express · 2025Article
- Effects of Curcumin on Biofilm Production and Associated Gene in Multidrug-ResistantInternational journal of molecular and cellular medicine · 2025Article
- Lonicera japonica protects Pelodiscus sinensis by inhibiting the biofilm formation of Aeromonas hydrophila.Applied microbiology and biotechnology · 2024Article
- Antibiofilm activity of Morganella morganii JB8F and Pseudomonas fluorescens JB3B compound to control single and multi-species of aquaculture pathogens.BMC microbiology · 2024Article
- Biocontrol of multidrug resistant pathogens isolated from fish farms using silver nanoparticles combined with hydrogen peroxide insight to its modulatory effect.Scientific reports · 2024Article
- Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.Applied microbiology and biotechnology · 2024Review
- Inhibitory effect of natural compounds on quorum sensing system inFrontiers in pharmacology · 2024Review
- Curcumin Aattenuates the Expression of Metalloprotease (AHA_0978) and Serine Protease (AHA_3857) Genes in Aeromonas Hydrophila.Galen medical journal · 2023Article
- Synergistic effects of silybin and curcumin on virulence and carbapenemase genes expression in multidrug resistant Klebsiella oxytoca.BMC research notes · 2022Article
- Impact of Omega-3 Fatty Acids Nano-Formulation on Growth, Antioxidant Potential, Fillet Quality, Immunity, Autophagy-Related Genes andAntioxidants (Basel, Switzerland) · 2022Article
- Antibacterial activity of supernatants of Lactoccocus lactis, Lactobacillus rhamnosus, Pediococcus pentosaceus and curcumin against Aeromonas hydrophila. In vitro study.Veterinary research communications · 2022Article
- Establishment of Epidemiological Resistance Cut-Off Values of AquaticMicroorganisms · 2022Article
- Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition.Scientific reports · 2021Article
- Quorum-quenching activity of some Iranian medicinal plants.New microbes and new infections · 2021Review
- Genistein Inhibits the Pathogenesis ofFrontiers in pharmacology · 2021Article
- Exploring Phenolic Compounds as Quorum Sensing Inhibitors in Foodborne Bacteria.Frontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS) in Aeromonas hydrophila is mainly based on the modulation of ahyI/R genes that regulates bacterial virulence determinant phenotypes. The use of QS inhibitors would be of particular interest in inhibiting bacterial pathogenicity and infections. In this study, we aimed to determine the effect of curcumin, a natural component of Curcuma longa, on the expression of QS regulating genes, ahyI and ahyR, as well as some QS regulated virulence characteristics in pathogenic fish isolated A. hydrophila strains. The minimum inhibitory concentration (MIC) of curcumin against bacteria was determined using the broth micro-dilution method and the expression of quorum sensing genes ahyI and ahyR among the bacteria treated with curcumin was determined using quantitative polymerase chain reaction (qPCR). Also, the effect of curcumin on some QS associated traits, including biofilm formation, swarming and swimming motility, proteolytic potential, and bacterial hemolytic activity was investigated. According to the results, curcumin, at a concentration of 32 µg/mL, significantly reduced the expression of both ahyI and ahyR genes among bacterial strains up to 64.2 and 91.0%, respectively. Moreover, curcumin efficiently inhibited bacterial biofilm formation, swimming, and swarming motility. Also, bacterial proteolytic activity was slightly reduced, while hemolytic activity was not significantly affected. This study demonstrated the use of curcumin to attenuate ahyI/R QS genes and several QS associated phenotypes in A. hydrophila. These findings indicate the therapeutic potential of curcumin as an anti-QS agent, to be used against A. hydrophila pathogenesis in aquaculture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.