SynthesisSurgical endoscopy2020
Efficacy of digital single-operator cholangioscopy in the visual interpretation of indeterminate biliary strictures: a systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07007832 (The Diagnostic Value of Bile-based Omics Analysis for Indeterminate Biliary Strictures), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Diagnostic Value of Bile-based Omics Analysis for Indeterminate Biliary Strictures
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Clinical Practice Guidelines for Peroral Cholangioscopy.Journal of hepato-biliary-pancreatic sciences · 2026Guideline
- Clinical practice guideline on the use of single-operator cholangioscopy in the diagnosis of indeterminate biliary stricture and the treatment of difficult biliary stones.Surgical endoscopy · 2024Guideline
- Trial
- Endoscopic findings of gallbladder lesions evaluated with image-enhanced endoscopy: A preliminary study using resected gallbladders.DEN open · 2026Article
- Feasibility of Novel Slim Peroral Cholangiopancreatoscopy for the Diagnosis of Pancreatobiliary Disease.DEN open · 2026Article
- Diagnosis of bile duct metastasis from gastric cancer by endoscopic retrograde cholangiopancreatography combined with choledochoscopy: A case report.World journal of gastrointestinal surgery · 2026Article
- Multimodal endoscopic diagnosis in biliary oncology: integrating EUS-guided tissue acquisition and cholangioscopy for personalized cancer care.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Article
- [On familiar terms with the bile and pancreatic ducts : Where is the benefit?]Innere Medizin (Heidelberg, Germany) · 2026Review
- European Consensus Recommendations for Direct Cholangioscopy and Pancreatoscopy Using a Modified Delphi Process.United European gastroenterology journal · 2025Article
- Diagnostic Yield of a Novel 11-Fr Digital Cholangioscope for Indeterminate Biliary Disease Using Macroscopic-On-Site Evaluation: Prospective Comparative Study.Journal of gastroenterology and hepatology · 2025Article
- Effectiveness of cholangioscopy guided biopsy versus ERCP guided brushings in diagnosing malignant biliary strictures.Surgical endoscopy · 2025Article
- Endoscopic treatment of unresectable perihilar cholangiocarcinoma: beyond biliary drainage.Therapeutic advances in gastroenterology · 2025Review
- An Approach to and Treatment of Indeterminate Biliary Strictures: A Comprehensive Review of the Literature.Journal of clinical medicine · 2024Review
- Cholangioscopy-based convoluted neuronal network vs. confocal laser endomicroscopy in identification of neoplastic biliary strictures.Endoscopy international open · 2024Article
- Atlas for Cholangioscopy and Cholecystoscopy: A Primer for Diagnostic and Therapeutic Endoscopy in the Biliary Tree and Gallbladder.Seminars in interventional radiology · 2024Review
- Accurate and safe diagnosis and treatment of neoplastic biliary lesions using a novel 9F and 11F digital single-operator cholangioscope.Endoscopy international open · 2024Article
- Case report: The diagnostic dilemma of indeterminate biliary strictures: report on two cases with a literature review.Frontiers in oncology · 2024Article
- Editorial: Role of imaging in biliary tract cancer: diagnosis, staging, response prediction and image-guided therapeutics.Frontiers in oncology · 2024Article
- The Role of Cholangioscopy in Biliary Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Role of peroral cholangioscopy and pancreatoscopy in the diagnosis and treatment of biliary and pancreatic disease: past, present, and future.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIndeterminate biliary strictures remain a significant diagnostic challenge. Digital single-operator cholangioscopy (D-SOC) incorporates digital imaging which enables higher resolution for better visualization and diagnosis of biliary pathology. We aimed to conduct a systematic review and meta-analysis of available literature in an attempt to determine the efficacy of D-SOC in the visual interpretation of indeterminate biliary strictures. MATERIAL AND
methodsElectronic searches were performed using Medline (PubMed), EMBASE, and Cochrane Library. All D-SOC studies that reported the diagnostic performance in visual interpretation of indeterminate biliary strictures and biliary malignancies were included. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 was used to evaluate the quality of the included studies. All data were extracted and pooled to construct a 2 × 2 table. The visual interpretation of D-SOC was compared to resected surgical specimens or clinical follow-up in the included patients. Pooled sensitivity, specificity, positive predictive value, negative predictive value, prevalence, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (OR) were calculated. The summarized receiver operating characteristic (SROC) curve corresponding with the area under the curve (AUC) was also analyzed.
resultsThe search yielded 465 citations. Of these, only six studies with a total of 283 procedures met inclusion criteria and were included in the meta-analysis. The overall pooled sensitivity and specificity of D-SOC in the visual interpretation of biliary malignancies was 94% (95% CI 89-97) and 95% (95%CI 90-98), respectively, while +LR, -LR, diagnostic OR, and AUC were 15.20 (95%CI 5.21-44.33), 0.08 (95%CI 0.04-0.14), 308.83 (95%CI 106.46-872.82), and 0.983, respectively. The heterogeneity among 6 included studies was moderate for specificity (I
conclusionD-SOC is associated with high sensitivity and specificity in the visual interpretation of indeterminate biliary strictures and malignancies. D-SOC should be considered routinely in the diagnostic workup of indeterminate biliary lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.