SynthesisWiener klinische Wochenschrift2020
Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.
Synthesis in Wiener klinische Wochenschrift, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Association of frailty and pre-frailty with cardiovascular mortality: a meta-analysis of 26 cohort studies.Frontiers in public health · 2025Pooled it
- Association between frailty and ischemic heart disease: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Frailty in acute coronary syndrome: From risk stratification to clinical decision-making.World journal of cardiology · 2026Review
- Frailty identifies early and non-cardiac healthcare utilization after cardiovascular hospitalization.Frontiers in cardiovascular medicine · 2026Article
- The Association of Myocardial Infarction History and Geriatric Syndromes in the Elderly: Data from the Cross-Sectional Study EVKALIPT.Journal of clinical medicine · 2024Article
- Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock.JACC. Advances · 2024Article
- Comment on: Benefit of primary and secondary prophylactic implantable cardioverter defibrillator in elderly patients.Clinical cardiology · 2024Article
- The association between frailty and in-hospital mortality in critically ill patients with congestive heart failure: results from MIMIC-IV database.Frontiers in cardiovascular medicine · 2024Article
- Frailty index based on laboratory tests improves prediction of short-and long-term mortality in patients with critical acute myocardial infarction.Frontiers in medicine · 2022Article
- Association between frailty and short- and long-term mortality in patients with critical acute myocardial infarction: Results from MIMIC-IV.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence from longitudinal studies linking frailty and outcome after acute coronary syndrome (ACS) is mixed. This systematic review and meta-analysis aimed to examine whether frailty is a predictor of all-cause mortality and hospital readmission in older patients with ACS.
methodsA systematic search was carried out in PubMed, EMBASE and Web of Science databases for studies evaluating the association between frailty and outcomes in older patients with ACS. A meta-analysis was performed to determine the pooled effect estimate for the association between frailty and mortality and hospital readmission, respectively.
resultsA total of 1459 articles were retrieved based on our search strategy. Fifteen studies involving 10,245 patients were included in the meta-analysis. The pooled prevalence of frailty was 32% (95% confidence interval [CI]: 25-39%), and the pooled prevalence of pre-frailty was 33% (95% CI: 26-40%) in elderly patients with ACS. Pooled analyses showed that frailty was associated with significantly higher risk of all-cause mortality and readmission (hazard ratios [HRs] = 2.43 and 2.32, respectively). Pre-frailty was also associated with significantly higher risk of all-cause mortality and readmission, respectively (HRs = 1.55 and 1.34, respectively).
conclusionsBoth frailty and pre-frailty are risk factors for all-cause mortality and readmission in older patients with ACS. Therefore, frailty assessment should be given sufficient attention in the management of older patients with ACS to help improve survival and reduce readmission rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.