ArticleEuropean radiology2020
Diagnostic accuracy of CT pulmonary angiography in suspected pulmonary hypertension.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- A systematic review of artificial intelligence tools for chronic pulmonary embolism on CT pulmonary angiography.Frontiers in radiology · 2024Pooled it
- Artificial Intelligence in Pulmonary Hypertension: Current State and Future Prospects.Reviews in cardiovascular medicine · 2026Review
- Explainable machine learning for early prediction and anatomical classification of pulmonary embolism in the emergency department.BMC emergency medicine · 2026Article
- Screening for Pulmonary Hypertension in Interstitial Lung Disease: Preliminary Results from the PHINDER Study.Advances in therapy · 2026Observational
- The New Era of Pulmonary Hypertension: The Dawn of Disease Modification & Therapeutic Modalities.Journal of cardiovascular development and disease · 2026Review
- Pulmonary Artery and Vein Morphology as an Imaging Biomarker for the Diagnosis of Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2026Article
- A fully automated explainable predictive model for diagnosing pre-capillary and post-capillary pulmonary hypertension on routine unenhanced CT: results from the ASPIRE registry.European heart journal. Digital health · 2026Article
- AI-based prediction of pulmonary hypertension in COPD patients with cor pulmonale using clinical and CT features.Frontiers in medicine · 2026Article
- Advances in the imaging of pulmonary hypertension.International journal of cardiology. Congenital heart disease · 2025Review
- Diagnostic value of fully automated CT pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease.European radiology · 2025Article
- Evaluation of Pulmonary Blood Flow, Right Atrium, Right Ventricle, and Pulmonary Artery in Patients After Pneumonectomy.Journal of clinical medicine · 2025Article
- Noninvasive assessment of pulmonary vascular resistance: a synergistic approach using computed tomography pulmonary angiography and echocardiography in pulmonary hypertension.Quantitative imaging in medicine and surgery · 2025Article
- Prognostic Impact of Right Ventricular Damage Markers on CT in Patients Undergoing TAVI.Life (Basel, Switzerland) · 2025Article
- Lung parenchymal and cardiac appearances on computed tomography pulmonary angiography impact survival in chronic thromboembolic pulmonary hypertension: results from the ASPIRE Registry.ERJ open research · 2025Article
- Prevalence, molecular mechanisms and diagnostic approaches to pulmonary arterial hypertension in connective tissue diseases.Rheumatology international · 2025Review
- The Role of Imaging in Pulmonary Vascular Disease: The Clinician's Perspective.Radiologic clinics of North America · 2025Review
- Article
- Impedance cardiography parameters reflecting left ventricular function are markers of pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2025Article
- Article
- Pulmonary hypertension in adults with congenital heart defects (ACHDs)-in light of the 2022 ESC PAH guidelines-part I: definition, epidemiology, classification, diagnostics, genetics, risk stratification and follow-up, gender aspects.Cardiovascular diagnosis and therapy · 2024Review
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesComputed tomography (CT) pulmonary angiography is widely used in patients with suspected pulmonary hypertension (PH). However, the diagnostic and prognostic significance remains unclear. The aim of this study was to (a) build a diagnostic CT model and (b) test its prognostic significance.
methodsConsecutive patients with suspected PH undergoing routine CT pulmonary angiography and right heart catheterisation (RHC) were identified. Axial and reconstructed images were used to derive CT metrics. Multivariate regression analysis was performed in the derivation cohort to identify a diagnostic CT model to predict mPAP ≥ 25 mmHg (the existing ESC guideline definition of PH) and > 20 mmHg (the new threshold proposed at the 6th World Symposium on PH). In the validation cohort, sensitivity, specificity and compromise CT thresholds were identified with receiver operating characteristic (ROC) analysis. The prognostic value of the CT model was assessed using Kaplan-Meier analysis.
resultsBetween 2012 and 2016, 491 patients were identified. In the derivation cohort (n = 247), a CT model was identified including pulmonary artery diameter, right ventricular outflow tract thickness, septal angle and left ventricular area. In the validation cohort (n = 244), the model was diagnostic, with an area under the ROC curve of 0.94/0.91 for mPAP ≥ 25/> 20 mmHg respectively. In the validation cohort, 93 patients died; mean follow-up was 42 months. The diagnostic thresholds for the CT model were prognostic, log rank, all p < 0.01. DISCUSSION: In suspected PH, a diagnostic CT model had diagnostic and prognostic utility. KEY POINTS: • Diagnostic CT models have high diagnostic accuracy in a tertiary referral population of with suspected PH. • Diagnostic CT models stratify patients by mortality in suspected PH.
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