Evidence map›Paper›PMID 32342115›Full record

ArticleDiabetologia2020

Selective stimulation of colonic L cells improves metabolic outcomes in mice.

Jo E Lewis, Emily L Miedzybrodzka, Rachel E Foreman, Orla R M Woodward, Richard G Kay, Deborah A Goldspink, Fiona M Gribble, Frank Reimann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  5. Incretin hormones and obesity.The Journal of physiology · 2025
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  11. Review
  12. Dorothy Hodgkin lecture 2023: The enteroendocrine system-Sensors in your guts.Diabetic medicine : a journal of the British Diabetic Association · 2023
    Review
  13. Review
  14. Article
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  16. RIIβ-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jo E LewisWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK.
Emily L MiedzybrodzkaWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK.
Rachel E ForemanWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK.
Orla R M WoodwardWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK.
Richard G KayWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK.
Deborah A GoldspinkWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK.
Fiona M GribbleWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK. fmg23@cam.ac.uk.
Frank ReimannWellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 OQQ, UK. fr222@cam.ac.uk.
University of Cambridge · GBWellcome/MRC Institute of Metabolic Science · GBWellcome Trust · GB

Funding

Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/3Medical Research Council MRC_MC_UU_12012/3Medical Research Council MR/M009041/1Wellcome Trust 106263Wellcome Trust 106263/Z/14/Z
6 · The paper itself

Abstract

aims/hypothesisInsulin-like peptide-5 (INSL5) is found only in distal colonic L cells, which co-express glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). GLP-1 is a well-known insulin secretagogue, and GLP-1 and PYY are anorexigenic, whereas INSL5 is considered orexigenic. We aimed to clarify the metabolic impact of selective stimulation of distal colonic L cells in mice.

methodsInsl5 promoter-driven expression of Gq-coupled Designer Receptor Exclusively Activated by Designer Drugs (DREADD) was employed to activate distal colonic L cells (L

resultsL CONCLUSIONS/

interpretationThis proof-of-concept study demonstrates that selective distal colonic L cell stimulation has beneficial metabolic outcomes. Graphical abstract.

Indexed as

AnimalsColonEnteroendocrine CellsGlucagon-Like Peptide 1InsulinL CellsMaleMicePeptide YYProteinsGlucagon-Like Peptide 1InsulinLeydig insulin-like proteinPeptide YYProteinsColonic L cellsEnteroendocrine cellsGLP-1Glucagon-like peptide-1INSL5Insulin-like peptide-5Peptide YYPYY

Identifiers

PMID32342115
PMCPMC7286941
OpenAlexW3019726148

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.