ReviewAIMS neuroscience2019
The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics.
Review in AIMS neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Association Between Freezing of Gait and Sleep Quality in People with Parkinson's Disease.Brain sciences · 2026Article
- Influence of posture on prepulse inhibition and its link to postural control in healthy subjects.Scientific reports · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Visualization of subthalamic nucleus on susceptibility weighted imaging and the verification of accuracy by microelectrode recording.Frontiers in human neuroscience · 2025Article
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.