Evidence map›Paper›PMID 32341898›Full record

ArticlePeerJ2020

Immune response of human cultured cells towards macrocyclic Fe

Alex J Salazar-Medina, Enrique F Velazquez-Contreras, Rocio Sugich-Miranda, Hisila Santacruz, Rosa E Navarro, Fernando Rocha-Alonzo, Maria A Islas-Osuna, Patricia L Chen, Sarah G B Christian, Amelia A Romoser and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alex J Salazar-MedinaCátedra CONACYT-Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora, Mexico.
Enrique F Velazquez-ContrerasDepartamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora, Mexico.
Rocio Sugich-MirandaDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, Sonora, Mexico.
Hisila SantacruzDepartamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora, Mexico.
Rosa E NavarroDepartamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora, Mexico.
Fernando Rocha-AlonzoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, Sonora, Mexico.
Maria A Islas-OsunaDepartamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora, Mexico.ORCID 0000-0002-7170-3366
Patricia L ChenComparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.
Sarah G B ChristianComparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.
Amelia A RomoserDepartment of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.
Scott V DindotDepartment of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.
Christie M SayesNanotoxicology and Nanopharmacology, RTI International, Research Triangle, MC, USA.ORCID 0000-0002-5529-4101
Rogerio R Sotelo-MundoBiomolecular Structure Laboratory, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora, Mexico.ORCID 0000-0001-5543-6889
Michael F CriscitielloComparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.ORCID 0000-0003-4262-7832

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic molecules that mimic the function of natural enzymes or molecules have untapped potential for use in the next generation of drugs. Cyclic compounds that contain aromatic rings are macrocyclic cyclophanes, and when they coordinate iron ions are of particular interest due to their antioxidant and biomimetic properties. However, little is known about the molecular responses at the cellular level. This study aims to evaluate the changes in immune gene expression in human cells exposed to the cyclophanes Fe

Indexed as

AntioxidantBiomimeticCD14CyclophanesGene expressionInterleukin 1IRAKIron

Identifiers

PMID32341898
PMCPMC7179565

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.