Evidence map›Paper›PMID 32341880›Full record

ArticleBiomedical optics express2020

High resolution 3D visualization of the spinal cord in a post-mortem murine model.

Inna Bukreeva, Victor Asadchikov, Alexey Buzmakov, Marina Chukalina, Anastasya Ingacheva, Nikolay A Korolev, Alberto Bravin, Alberto Mittone, Gabriele E M Biella, Alejandra Sierra and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Inna BukreevaInstitute of Nanotechnology- CNR, Rome Unit, Piazzale Aldo Moro 5, Italy.ORCID https://orcid.org/0000-0003-1483-4965
Victor AsadchikovShubnikov Institute of Crystallography FSRC "Crystallography and Photonics" RAS, Leninsky prosp., 59, Moscow, Russia.ORCID https://orcid.org/0000-0003-3602-7582
Alexey BuzmakovShubnikov Institute of Crystallography FSRC "Crystallography and Photonics" RAS, Leninsky prosp., 59, Moscow, Russia.
Marina ChukalinaShubnikov Institute of Crystallography FSRC "Crystallography and Photonics" RAS, Leninsky prosp., 59, Moscow, Russia.
Anastasya IngachevaIntitute for Information Transmission Problems RAS, Bolshoi Karetny per, 9, Moscow, Russia.
Nikolay A KorolevNational Research Nuclear University /Moscow Engineering Physics Institute, Kashirskoye Highway, 31 Moscow, Russia.
Alberto BravinEuropean Synchrotron Radiation Facility, 71 Avenue des Martyrs, Grenoble, France.
Alberto MittoneCELLS - ALBA Synchrotron Light Source, Carrer de la Llum, 2-26, Cerdanyola del Valles, Barcelona, Spain.
Gabriele E M BiellaIBFM-CNR, Via Fratelli Cervi, 93 - 20090 Segrate-Milan, Italy.
Alejandra SierraBiomedical Imaging Unit, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Francesco BrunDepartment of Engineering and Architecture, University of Trieste, Via A. Valerio, 6/1 Trieste, Italy.
Lorenzo MassimiDepartment of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
Michela FratiniInstitute of Nanotechnology- CNR, Rome Unit, Piazzale Aldo Moro 5, Italy.
Alessia CedolaInstitute of Nanotechnology- CNR, Rome Unit, Piazzale Aldo Moro 5, Italy.
A.V. Shubnikov Institute of Crystallography · RUInstitute for Information Transmission Problems · RUInstitute of Nanotechnology · GBALBA Synchrotron (Spain) · ESEuropean Synchrotron Radiation Facility · FRInstitute of Molecular Bioimaging and Physiology · ITNational Research Nuclear University MEPhI · RUP.N. Lebedev Physical Institute of the Russian Academy of Sciences · RUUniversity College London · GBUniversity of Eastern Finland · FIUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A crucial issue in the development of therapies to treat pathologies of the central nervous system is represented by the availability of non-invasive methods to study the three-dimensional morphology of spinal cord, with a resolution able to characterize its complex vascular and neuronal organization. X-ray phase contrast micro-tomography enables a high-quality, 3D visualization of both the vascular and neuronal network simultaneously without the need of contrast agents, destructive sample preparations or sectioning. Until now, high resolution investigations of the post-mortem spinal cord in murine models have mostly been performed in spinal cords removed from the spinal canal. We present here post-mortem phase contrast micro-tomography images reconstructed using advanced computational tools to obtain high-resolution and high-contrast 3D images of the fixed spinal cord without removing the bones and preserving the richness of micro-details available when measuring exposed spinal cords. We believe that it represents a significant step toward the in-vivo application.

Identifiers

PMID32341880
PMCPMC7173906
OpenAlexW3009961861

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.