ArticleBiomedical optics express2020
Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Crystalline Lens Tilts Less With Higher Myopia in Children With Limited Age-Related Effect.Translational vision science & technology · 2026Article
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- Quantifying age and spatial variations of bone marrow elasticity with noncontact optical coherence elastography.Journal of biomedical optics · 2025Article
- Clinical multimodal Brillouin microscopy-optical coherence elastography system for lens biomechanics.Journal of biomedical optics · 2025Article
- In Vivo Safety Evaluation of Acoustic Radiation Force for Optical Coherence Elastography of the Crystalline Lens.Translational vision science & technology · 2025Article
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- Brillouin Metrics of the Crystalline Lens Comparison Between Low-Medium Myopia and High Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Article
- Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture.IEEE open journal of engineering in medicine and biology · 2025Article
- Acoustic Radiation Force Optical Coherence Elastography of the Crystalline Lens: Safety.Translational vision science & technology · 2024Article
- Dual optical elastography detectsJournal of biomedical optics · 2024Article
- Optical coherence tomography quantifies gradient refractive index and mechanical stiffness gradient across the human lens.Communications medicine · 2024Article
- Functional effects of the spatial-varying lens mechanical properties in accommodation.JPhys photonics · 2024Article
- Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant.Development (Cambridge, England) · 2024Article
- Model of zonular forces on the lens capsule during accommodation.Scientific reports · 2024Article
- The potential influence of the ligament of Wieger on the crystalline lens shape.Scientific reports · 2024Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Storage-induced mechanical changes of porcine lenses assessed with optical coherence elastography and inverse finite element modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Photoacoustic elasto-viscography and optical coherence microscopy for multi-parametricBiomedical optics express · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Assessing the biomechanical properties of the crystalline lens can provide crucial information for diagnosing disease and guiding precision therapeutic interventions. Existing noninvasive methods have been limited to global measurements. Here, we demonstrate the quantitative assessment of the elasticity of crystalline lens with a multimodal optical elastography technique, which combines dynamic wave-based optical coherence elastography (OCE) and Brillouin microscopy to overcome the drawbacks of individual modalities. OCE can provide direct measurements of tissue elasticity rapidly and quantitatively, but it is a challenge to image transparent samples such as the lens because this technique relies on backscattered light. On the other hand, Brillouin microscopy can map the longitudinal modulus with micro-scale resolution in transparent samples. However, the relationship between Brillouin-deduced modulus and Young's modulus is not straightforward and sample dependent. By combining these two techniques, we can calibrate Brillouin measurements with OCE, based on the same sample, allowing us to completely map the Young's modulus of the crystalline lens. The combined system was first validated with tissue-mimicking gelatin phantoms of varying elasticities (N = 9). The OCE data was used to calibrate the Brillouin shift measurements and subsequently map the Young's modulus of the phantoms. After validation, OCE and Brillouin measurements were performed on
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.