Evidence map›Paper›PMID 32341851›Full record

ArticleBiomedical optics express2020

Automated morphometric measurement of the retinal pigment epithelium complex and choriocapillaris using swept source OCT.

Hao Zhou, Yining Dai, Giovanni Gregori, Philip R Rosenfeld, Jacque L Duncan, Daniel M Schwartz, Ruikang K Wang

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025
    Article
  6. The Impact of Carotid Endarterectomy on Choriocapillaris Perfusion.Investigative ophthalmology & visual science · 2023
    Observational
  7. Article
  8. Article
  9. Article
  10. Choriocapillaris Changes in Myopic Macular Degeneration.Translational vision science & technology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hao ZhouDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA.ORCID https://orcid.org/0000-0003-0068-5102
Yining DaiDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Giovanni GregoriDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Philip R RosenfeldDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Jacque L DuncanDepartment of Ophthalmology, University of California, San Francisco, CA 94143, USA.
Daniel M SchwartzDepartment of Ophthalmology, University of California, San Francisco, CA 94143, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA.ORCID https://orcid.org/0000-0001-5169-8822
University of Washington · USUniversity of California, San Francisco · USUniversity of Miami · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8M
Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathyR01EY028753 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2018 to 2021
$2.2M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY028753
6 · The paper itself

Abstract

We report the development of an automated method to measure morphological features of the retinal pigment epithelium (RPE), Bruch's membrane (BM) and choriocapillaris (CC) using a commercially available swept source OCT (SS-OCT) system. The locations of the inner segment/outer segment (IS/OS), RPE and CC were determined by optical coherence tomography (OCT) and OCT angiography (OCTA) A-scan intensity profiles, which were used to calculate the mean IS/OS-to-RPE distance, mean RPE-to-CC distance, mean RPE-to-CC outer boundary distance, mean RPE thickness and mean CC thickness across the entire scan volume. The automated method was tested on two groups of normal subjects: younger age group (n=20, 30.3 ± 5.72 years, axial length = 24.2 ± 0.96 mm) and older age group (n=20, 80.8 ± 4.12 years, axial length = 23.5 ± 0.93 mm). The 6×6 mm macular scans were acquired from one eye of each subject. Repeatability of the measurements showed a coefficient of variance < 5% for all the cases. CC locations were confirmed qualitatively with pixel-by-pixel moving of the

Identifiers

PMID32341851
PMCPMC7173887
OpenAlexW3010397698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.