ArticleBMJ open sport & exercise medicine2020
Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria.
Article in BMJ open sport & exercise medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Effects of exercise on urinary biochemical parameters and proteins in a group of well-trained military working dogs.The veterinary quarterly · 2023Article
- Postexercise urinary alpha-1 acid glycoprotein is not dependent on hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m).BMJ open sport & exercise medicine · 2021Article
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Authors and funding
20 authors at 8 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionProteinuria increases at altitude and with exercise, potentially as a result of hypoxia. Using urinary alpha-1 acid glycoprotein (α1-AGP) levels as a sensitive marker of proteinuria, we examined the impact of relative hypoxia due to high altitude and blood pressure-lowering medication on post-exercise proteinuria.
methodsTwenty individuals were pair-matched for sex, age and ACE genotype. They completed maximal exercise tests once at sea level and twice at altitude (5035 m). Losartan (100 mg/day; angiotensin-receptor blocker) and placebo were randomly assigned within each pair 21 days before ascent. The first altitude exercise test was completed within 24-48 hours of arrival (each pair within ~1 hour). Acetazolamide (125 mg two times per day) was administrated immediately after this test for 48 hours until the second altitude exercise test.
resultsWith placebo, post-exercise α1-AGP levels were similar at sea level and altitude. Odds ratio (OR) for increased resting α1-AGP at altitude versus sea level was greater without losartan (2.16 times greater). At altitude, OR for reduced post-exercise α1-AGP (58% lower) was higher with losartan than placebo (2.25 times greater, p=0.059) despite similar pulse oximetry (SpO DISCUSSION: Profound systemic hypoxia imposed by altitude does not result in greater post-exercise proteinuria than sea level. Losartan and acetazolamide may attenuate post-exercise proteinuria, however further research is warranted.
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