ArticleTherapeutic advances in chronic disease2020
D-mannose attenuates bone loss in mice
Article in Therapeutic advances in chronic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Metabolomic biomarkers of low BMD: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics.Burns & trauma · 2026Review
- Ginkgolide B modulates the gut-bone axis to ameliorate bone loss in ovariectomized mice.Journal of orthopaedic surgery and research · 2025Article
- Mechanical and biological properties of 3D-printed porous titanium scaffolds coated with composite growth factors.BMC oral health · 2025Article
- Gut Microbiota Modulation in Osteoporosis: Probiotics, Prebiotics, and Natural Compounds.Metabolites · 2025Review
- A Comprehensive Analysis of Chemical Composition and Anti-Inflammatory Effects of Cassava Leaf Extracts in Two Varieties inInternational journal of molecular sciences · 2025Article
- T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration.Journal of orthopaedic translation · 2025Review
- D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils.BMC oral health · 2024Article
- Utilizing surface-enhanced Raman spectroscopy for the adjunctive diagnosis of osteoporosis.European journal of medical research · 2024Article
- Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β-catenin signaling pathways.Animal models and experimental medicine · 2024Article
- D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder.Developmental cell · 2024Article
- From gut to bone: deciphering the impact of gut microbiota on osteoporosis pathogenesis and management.Frontiers in cellular and infection microbiology · 2024Review
- Mannose: A Promising Player in Clinical and Biomedical Applications.Current drug delivery · 2024Review
- D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis.Frontiers in pharmacology · 2024Article
- D-mannose reduces adipogenesis by inhibiting the PI3K/AKT signaling pathway.Histology and histopathology · 2023Article
- Amelioration of Rheumatoid Arthritis byMedicina (Kaunas, Lithuania) · 2023Article
- D-Mannose prevents bone loss under weightlessness.Journal of translational medicine · 2023Article
- Fecal microbiota transplantation as a promising treatment option for osteoporosis.Journal of bone and mineral metabolism · 2022Review
- Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis.iScience · 2022Article
- Mannose Attenuates Colitis-Associated Colorectal Tumorigenesis by Targeting Tumor-Associated Macrophages.Journal of cancer prevention · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundD-mannose exhibits strong anti-inflammatory properties, but whether it has beneficial effects on preventing and treating osteoporosis remains unknown.
methodsFemale, 12-month-old senile C57BL6/J mice (s-Man group) and 8-week-old ovariectomized C57BL6/J mice (OVX-Man group) were treated with D-mannose in drinking water for 2 months (six mice/group). Microcomputed tomography analysis and hematoxylin and eosin staining were performed to investigate the effect of D-mannose on attenuation of bone loss. Tartrate-resistant acid phosphatase staining of tissue sections, flow cytometry, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gut microbiome biodiversity tests were used to explore the underlying mechanisms.
resultsD-mannose-induced marked increases in cortical bone volume and trabecular bone microarchitecture in the s-Man and OVX-Man group compared with that in the s-CTRL (senile control) and OVX group, respectively. Moreover, D-mannose downregulated osteoclastogenesis-related cytokines in the bone marrow and expanded regulatory T cells in the spleen of mice. Furthermore, D-mannose reconstructed the gut microbiota and changed the metabolite composition.
conclusionD-mannose attenuated bone loss induced by senility and estrogen deficiency in mice, and this effect may be mediated by D-mannose-induced proliferation of regulatory T cells and gut microbiota-dependent anti-inflammatory effects.
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