Evidence map›Paper›PMID 32341754›Full record

ArticleOncotarget2020

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model.

Vijay R Gupta, Adam Root, Timothy Fisher, Rand Norberg, John David, Tracey Clark, Justin Cohen, Chad May, Anand Giddabasappa

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Vijay R GuptaGlobal Science & Technology (GST) - Comparative Medicine, Pfizer Global Research Development and Medical, San Diego, CA 92121, USA.
Adam RootBioMedicine Design, Cambridge, MA 02139, USA.
Timothy FisherOncology Research and Development, San Diego, CA 92121, USA.
Rand NorbergGlobal Science & Technology (GST) - Comparative Medicine, Pfizer Global Research Development and Medical, San Diego, CA 92121, USA.
John DavidGlobal Science & Technology (GST) - Comparative Medicine, Pfizer Global Research Development and Medical, San Diego, CA 92121, USA.
Tracey ClarkPDM Biotherapeutics, Pfizer Inc., San Diego, CA 92121, USA.
Justin CohenBioMedicine Design, Cambridge, MA 02139, USA.
Chad MayOncology Research and Development, San Diego, CA 92121, USA.
Anand GiddabasappaGlobal Science & Technology (GST) - Comparative Medicine, Pfizer Global Research Development and Medical, San Diego, CA 92121, USA.
Pfizer (United States) · USPCR Oncology · USGlobal Science & Technology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P-cadherin-LP-DART is a bispecific antibody targeting P-cadherin expressed on the tumor cells and CD3 on the T-cells. Previously we demonstrated the development and efficacy of P-cadherin-LP-DART in

Indexed as

biodistributionbispecific antibodymolecular imagingT cellstumor targeting

Identifiers

PMID32341754
PMCPMC7170501
OpenAlexW3016654729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.