ArticleCellular & molecular immunology2021
Ectopic Tcf1 expression instills a stem-like program in exhausted CD8
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Article in Cellular & molecular immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review.Frontiers in immunology · 2026Pooled it
- All-trans retinoic acid suppresses CD8Signal transduction and targeted therapy · 2026Article
- Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.The Journal of clinical investigation · 2026Article
- Single-cell gain-of-function mapping reveals latent regulatory programs governing CD8Research square · 2026Article
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- β-hydroxybutyrate potentiates anti-tumor immunity by modulating cytotoxic CD8Cancer immunology, immunotherapy : CII · 2026Article
- Recapitulating the qualities of HIV-specific CD8 + T cells from spontaneous controllers.Current opinion in HIV and AIDS · 2026Review
- Memory programming and new manufacturing paradigms in CAR-T cell therapy.Cancer gene therapy · 2026Review
- Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions.MedComm · 2026Review
- High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.Nature communications · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Cytotoxic lymphocyte heterogeneity in glioblastoma: insights from single-cell and spatial multiomics toward precision immunotherapeutic reprogramming.Frontiers in immunology · 2026Review
- Next-generation CAR-T cells design: leveraging tumor features for enhanced efficacy.Molecular cancer · 2025Review
- GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells.Science immunology · 2025Article
- The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8Immunity · 2025Article
- Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy.Cellular & molecular immunology · 2025Review
- HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection.The Journal of experimental medicine · 2025Article
- BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells.The Journal of experimental medicine · 2025Article
- Immune regeneration: implications for cancer immunotherapy and beyond.The Journal of clinical investigation · 2025Review
- Hdac1 as an early determinant of intermediate-exhausted CD8Proceedings of the National Academy of Sciences of the United States of America · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Qiang Shan *Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, 07110, USA.
Sheng'en Hu *Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Xia ChenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, 07110, USA.
Derek B DanahyDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Vladimir P BadovinacDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Chongzhi ZangCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. zang@virginia.edu.ORCID http://orcid.org/0000-0003-4812-3627
Hai-Hui XueCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, 07110, USA. haihui.xue@hmh-cdi.org.ORCID http://orcid.org/0000-0002-9163-7669
University of Iowa · USUniversity of Virginia · US
Funding
Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4MTcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6MMemory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4MIntegrative computational models for functional epigenomics and transcriptional regulationR35GM133712 · NIGMS · UNIVERSITY OF VIRGINIA · PI Chongzhi Zang · 2019 to 2026
$3.4MEzh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4MCellular and molecular mechanisms controlling sepsis-induced immunoparalyses stateR35GM134880 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2020 to 2024
$1.9MImpairment and recovery of CD8 T cell responses after sepsisR01GM113961 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2015 to 2018
$1.2MDifferentiation of pathogen-specific memory CD8 T cell responsesR21AI147064 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2019 to 2020
$424kTargeting Tcf/Lef-transcriptional program in leukemic stem cellsI01BX002903 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2016 to 2019
–BLRD VA I01 BX002903NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874NIAID NIH HHS R21 AI147064NIGMS NIH HHS R01 GM113961NIGMS NIH HHS R35 GM133712NIGMS NIH HHS R35 GM134880
Abstract
Exhausted CD8
Indexed as
ImmunityAnimalsCD8-Positive T-LymphocytesCell CycleCell SurvivalChromatinGene Expression RegulationHepatocyte Nuclear Factor 1-alphaLymphocytes, Tumor-InfiltratingLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMice, TransgenicNeoplasmsPrincipal Component AnalysisStem CellsTranscriptomeChromatinHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseStem cell featuresT cell exhaustionTcf1
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.