Evidence map›Paper›PMID 32341488›Full record

ArticleEuropean journal of clinical nutrition2020

Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study.

Anupam Chandra, Helge Røsjø, My Svensson, Thea Vigen, Håkon Ihle-Hansen, Eivind Bjørkan Orstad, Ole Morten Rønning, Magnus Nakrem Lyngbakken, Ståle Nygård, Trygve Berge and 4 more

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01555411 (Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01555411 active not recruitingnot on this map

Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects

TypeobservationalSponsorVestre Viken Hospital TrustRan2012 to 2050Enrolled3,706ConditionsAtrial Fibrillation, Heart Failure, Mild Cognitive Impairment, Cardiovascular Diseases
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Anupam ChandraDepartment of Renal Medicine, Division of Medicine, Akershus University Hospital, Lørenskog, Norway. Anupam.Chandra@ahus.no.
Helge RøsjøInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
My SvenssonDepartment of Renal Medicine, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Thea VigenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Håkon Ihle-HansenDepartment of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
Eivind Bjørkan OrstadDivision of Medicine, Akershus University Hospital, Lørenskog, Norway.
Ole Morten RønningInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Magnus Nakrem LyngbakkenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ståle NygårdCentre for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-5263-4748
Trygve BergeDepartment of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
Erik Berg SchmidtDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Torbjørn OmlandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Arnljot TveitInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ivar Anders EideDepartment of Renal Medicine, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
University of Oslo · NOAkershus University Hospital · NOVestre Viken Hospital Trust · NOAalborg University Hospital · DKOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA high intake of linoleic acid (LA), the major dietary polyunsaturated fatty acid (PUFA), has previously been associated with reduced cardiovascular (CV) morbidity and mortality in observational studies. However, recent secondary analyses from clinical trials of LA-rich diet suggest harmful effects of LA on CV health.

methodsA total of 3706 participants, all born in 1950, were included in this cross-sectional study. We investigated associations between plasma phospholipid levels of LA and CV risk factors in a Norwegian general population, characterized by a relative low LA and high marine n-3 PUFA intake. The main statistical approach was multivariable linear regression.

resultsPlasma phospholipid LA levels ranged from 11.4 to 32.0 wt%, with a median level of 20.8 wt% (interquartile range 16.8-24.8 wt%). High plasma LA levels were associated with lower serum low-density lipoprotein cholesterol levels (standardized regression coefficient [Std. β-coeff.] -0.04, p = 0.02), serum triglycerides (Std. β-coeff. -0.10, p < 0.001), fasting plasma glucose (Std. β-coeff. -0.10, p < 0.001), body mass index (Std. β-coeff. -0.13, p < 0.001), systolic and diastolic blood pressure (Std. β-coeff. -0.04, p = 0.03 and Std. β-coeff. -0.02, p = 0.02, respectively) and estimated glomerular filtration rate (Std. β-coeff. -0.09, p < 0.001). We found no association between plasma LA levels and high-density lipoprotein cholesterol levels, glycated hemoglobin, carotid intima-media thickness, or C-reactive protein.

conclusionHigh plasma LA levels were favorably associated with several CV risk factors in this study of a Norwegian general population.

Indexed as

Carotid Intima-Media ThicknessLinoleic AcidAgedCross-Sectional StudiesDietHumansNorwayRisk FactorsLinoleic Acid

Identifiers

PMID32341488
OpenAlexW3019308555

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.