Evidence map›Paper›PMID 32341480›Full record

ArticleNature microbiology2020

Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity.

Livia V Patrono, Kamilla Pléh, Liran Samuni, Markus Ulrich, Caroline Röthemeier, Andreas Sachse, Silvia Muschter, Andreas Nitsche, Emmanuel Couacy-Hymann, Christophe Boesch and 3 more

Abstract read
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In one paragraph

Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Livia V Patrono *Project Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Kamilla Pléh *Project Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Liran SamuniTaï Chimpanzee Project, Centre Suisse de Recherches Scientifiques, Abidjan, Ivory Coast.
Markus UlrichProject Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Caroline RöthemeierProject Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Andreas SachseProject Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Silvia MuschterCentre for Biological Threats and Special Pathogens and German Reference Laboratory for Poxviruses (ZBS1), Robert Koch Institute, Berlin, Germany.
Andreas NitscheCentre for Biological Threats and Special Pathogens and German Reference Laboratory for Poxviruses (ZBS1), Robert Koch Institute, Berlin, Germany.
Emmanuel Couacy-HymannLaboratoire National D'appui au Développement Agricole/Laboratoire Central de Pathologie Animale, Bingerville, Ivory Coast.
Christophe BoeschTaï Chimpanzee Project, Centre Suisse de Recherches Scientifiques, Abidjan, Ivory Coast.
Roman M WittigTaï Chimpanzee Project, Centre Suisse de Recherches Scientifiques, Abidjan, Ivory Coast.ORCID http://orcid.org/0000-0001-6490-4031
Sébastien Calvignac-SpencerProject Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Fabian H LeendertzProject Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany. LeendertzF@rki.de.ORCID http://orcid.org/0000-0002-2169-7375
Robert Koch Institute · DEMax Planck Institute for Evolutionary Anthropology · DELaboratoire National d'Appui au Développement Agricole · CI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan troglodytes verus, hereafter chimpanzee) population from Taï National Park, Ivory Coast. Through daily monitoring, we show that further to causing its typical exanthematous syndrome, monkeypox can present itself as a severe respiratory disease without a diffuse rash. By analysing 949 non-invasively collected samples, we identify the circulation of at least two distinct monkeypox virus lineages and document the shedding of infectious particles in faeces and flies, suggesting that they could mediate indirect transmission. We also show that the carnivorous component of the Taï chimpanzees' diet, mainly consisting of the sympatric monkeys they regularly hunt, did not change nor shift towards rodent consumption (the presumed reservoir) before the outbreaks, suggesting that the sudden emergence of monkeypox virus in this population is probably due to changes in the ecology of the virus itself. Using long-term mortality surveillance data from Taï National Park, we provide evidence of little to no prior viral activity over at least two decades. We conclude that great ape sentinel systems devoted to the longitudinal collection of behavioural and health data can help clarify the epidemiology and clinical presentation of zoonotic pathogens.

Indexed as

Animals, WildAnimalsEcosystemExanthemaExtracellular SpaceFecesGenome, ViralGenomicsGlutathioneHigh-Throughput Nucleotide SequencingMonkeypox virusMpox, MonkeypoxPan troglodytesPhylogenyRespiration DisordersGlutathione

Identifiers

PMID32341480
OpenAlexW3013868197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.