Evidence map›Paper›PMID 32341425›Full record

ArticleScientific reports2020

Graphene Quantum Dot Oxidation Governs Noncovalent Biopolymer Adsorption.

Sanghwa Jeong, Rebecca L Pinals, Bhushan Dharmadhikari, Hayong Song, Ankarao Kalluri, Debika Debnath, Qi Wu, Moon-Ho Ham, Prabir Patra, Markita P Landry

Abstract read
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In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Holistic Investigation of Graphene Quantum Dot Endocytosis.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sanghwa Jeong *Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
Rebecca L Pinals *Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
Bhushan DharmadhikariDepartment of Electrical and Computer Engineering & Technology, Minnesota State University, Mankato, MA, 56001, USA.
Hayong SongSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.
Ankarao KalluriDepartment of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, 06604, USA.
Debika DebnathDepartment of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, 06604, USA.
Qi WuDepartment of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, 06604, USA.
Moon-Ho HamSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.
Prabir PatraDepartment of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, 06604, USA. ppatra@bridgeport.edu.
Markita P LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA. landry@berkeley.edu.

Funding

Single-Molecule Imaging of Biological Trauma:Cytokine-Based Intracellular CommunicationR35GM128922 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDRY, MARKITA · 2019 to 2023
$2.0M
High Performance Computing Cluster for Public Health Driven Molecular Science - Core FacilityS10OD023532 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DURKIN, KATHLEEN A · 2017 to 2017
$434k
Optical montoring of modulatory neurotransmitter levels using new infrared nanonsensorsR21DA044010 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILBRECHT, LINDA E · 2017 to 2018
$323k
NIDA NIH HHS R21 DA044010NIGMS NIH HHS R35 GM128922NIH HHS S10 OD023532
6 · The paper itself

Abstract

Graphene quantum dots (GQDs) are an allotrope of carbon with a planar surface amenable to functionalization and nanoscale dimensions that confer photoluminescence. Collectively, these properties render GQDs an advantageous platform for nanobiotechnology applications, including optical biosensing and delivery. Towards this end, noncovalent functionalization offers a route to reversibly modify and preserve the pristine GQD substrate, however, a clear paradigm has yet to be realized. Herein, we demonstrate the feasibility of noncovalent polymer adsorption to GQD surfaces, with a specific focus on single-stranded DNA (ssDNA). We study how GQD oxidation level affects the propensity for polymer adsorption by synthesizing and characterizing four types of GQD substrates ranging ~60-fold in oxidation level, then investigating noncovalent polymer association to these substrates. Adsorption of ssDNA quenches intrinsic GQD fluorescence by 31.5% for low-oxidation GQDs and enables aqueous dispersion of otherwise insoluble no-oxidation GQDs. ssDNA-GQD complexation is confirmed by atomic force microscopy, by inducing ssDNA desorption, and with molecular dynamics simulations. ssDNA is determined to adsorb strongly to no-oxidation GQDs, weakly to low-oxidation GQDs, and not at all for heavily oxidized GQDs. Finally, we reveal the generality of the adsorption platform and assess how the GQD system is tunable by modifying polymer sequence and type.

Indexed as

Molecular Dynamics SimulationDNA, Single-StrandedFluorescenceGraphiteQuantum DotsDNA, Single-Strandedgraphene oxideGraphite

Identifiers

PMID32341425
PMCPMC7184744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.