Evidence map›Paper›PMID 32341414›Full record

Trial reportScientific reports2020

Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania.

Rebecca F Bodenham, AbdulHamid S Lukambagire, Roland T Ashford, Joram J Buza, Shama Cash-Goldwasser, John A Crump, Rudovick R Kazwala, Venance P Maro, John McGiven, Nestory Mkenda and 9 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 57 citations in OpenAlex.

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  9. Pathogens (Basel, Switzerland) · 2024
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  12. Complete genome sequence ofMicrobiology resource announcements · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 5 countries.

Rebecca F BodenhamInstitute of Biodiversity, Animal Health & Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
AbdulHamid S LukambagireSokoine University of Agriculture, Morogoro, Tanzania.
Roland T AshfordOIE/FAO Brucellosis Reference Laboratory, Department of Bacteriology, Animal & Plant Health Agency, Surrey, UK.
Joram J BuzaNelson Mandela African Institution for Science and Technology, Arusha, Tanzania.
Shama Cash-GoldwasserDuke Global Health Institute, Duke University, Durham, North Carolina, USA.
John A CrumpDuke Global Health Institute, Duke University, Durham, North Carolina, USA.
Rudovick R KazwalaSokoine University of Agriculture, Morogoro, Tanzania.
Venance P MaroKilimanjaro Christian Medical Centre, Moshi, Tanzania.
John McGivenOIE/FAO Brucellosis Reference Laboratory, Department of Bacteriology, Animal & Plant Health Agency, Surrey, UK.
Nestory MkendaEndulen Hospital, Ngorongoro Conservation Area, Arusha, Tanzania.
Blandina T MmbagaDuke Global Health Institute, Duke University, Durham, North Carolina, USA.
Matthew P RubachDuke Global Health Institute, Duke University, Durham, North Carolina, USA.
Philoteus SakasakaKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Gabriel M ShirimaNelson Mandela African Institution for Science and Technology, Arusha, Tanzania.
Emanuel S SwaiDirectorate of Veterinary Services, Ministry of Livestock and Fisheries, Dodoma, Tanzania.
Kate M ThomasKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Adrian M WhatmoreOIE/FAO Brucellosis Reference Laboratory, Department of Bacteriology, Animal & Plant Health Agency, Surrey, UK.
Daniel T HaydonInstitute of Biodiversity, Animal Health & Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Jo E B HallidayInstitute of Biodiversity, Animal Health & Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. jo.halliday@glasgow.ac.uk.
Kilimanjaro Christian Medical Centre · TZAnimal and Plant Health Agency · GBUniversity of Glasgow · GBNelson Mandela African Institution of Science and Technology · TZSokoine University of Agriculture · TZDuke Institute for Health Innovation · USDuke Medical Center · USMinistry of Livestock and Fisheries · TZTanzania National Parks · TZ

Funding

Investigating Febrile Deaths in Tanzania (INDITe)R01AI121378 · NIAID · DUKE UNIVERSITY · PI RUBACH, MATTHEW P · 2016 to 2020
$2.7M
Biotechnology and Biological Sciences Research Council BB/L017679Biotechnology and Biological Sciences Research Council BB/L018845/1Biotechnology and Biological Sciences Research Council BB/L018926Biotechnology and Biological Sciences Research Council BB/S013857/1EPA EP-C-15-008NIAID NIH HHS R01 AI121378
6 · The paper itself

Abstract

Brucellosis is an endemic zoonosis in sub-Saharan Africa. Pastoralists are at high risk of infection but data on brucellosis from these communities are scarce. The study objectives were to: estimate the prevalence of human brucellosis, identify the Brucella spp. causing illness, describe non-Brucella bloodstream infections, and identify risk factors for brucellosis in febrile patients from a pastoralist community of Tanzania. Fourteen (6.1%) of 230 participants enrolled between August 2016 and October 2017 met study criteria for confirmed (febrile illness and culture positivity or ≥four-fold rise in SAT titre) or probable (febrile illness and single SAT titre ≥160) brucellosis. Brucella spp. was the most common bloodstream infection, with B. melitensis isolated from seven participants and B. abortus from one. Enterococcus spp., Escherichia coli, Salmonella enterica, Staphylococcus aureus and Streptococcus pneumoniae were also isolated. Risk factors identified for brucellosis included age and herding, with a greater probability of brucellosis in individuals with lower age and who herded cattle, sheep or goats in the previous 12 months. Disease prevention activities targeting young herders have potential to reduce the impacts of human brucellosis in Tanzania. Livestock vaccination strategies for the region should include both B. melitensis and B. abortus.

Indexed as

Animal HusbandryBrucellosisAnimalsBrucella abortusBrucella melitensisCattleFemaleGoatsHumansLivestockMaleOccupational ExposurePrevalenceSheepTanzania

Identifiers

PMID32341414
PMCPMC7184621
OpenAlexW3018609674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.