Evidence map›Paper›PMID 32341396›Full record

ArticleScientific reports2020

Variation of 4 MV X-ray dose rate strongly impacts biological response both in vitro and in vivo.

M Ben Kacem, M A Benadjaoud, M Dos Santos, F Soysouvanh, V Buard, G Tarlet, B Le Guen, A François, O Guipaud, F Milliat and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

M Ben KacemInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
M A BenadjaoudInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of Radiobiology and Regenerative Medicine (SERAMED), Fontenay-aux-Roses, France.
M Dos SantosInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of Radiobiology and Regenerative Medicine (SERAMED), Laboratory of Radiobiology of Accidental Exposures (LRAcc), Fontenay-aux-Roses, France.
F SoysouvanhInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
V BuardInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
G TarletInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
B Le GuenElectricité de France, Cap Ampère, Saint-Denis, France.
A FrançoisInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
O GuipaudInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
F MilliatInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France.
V PagetInstitute for Radiological Protection and Nuclear Safety (IRSN), Department of RAdiobiology and Regenerative Medicine (SERAMED), Laboratory of Medical Radiobiology (LRMed), Fontenay-aux-Roses, 92260, France. vincent.paget@irsn.fr.ORCID http://orcid.org/0000-0002-3335-7386
Institut de Radioprotection et de Sûreté Nucléaire · FRÉlectricité de France (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whereas an RBE > 1 is described for very low-energy X-ray beams (in the range of 25-50 kV), there is a consensus that the RBE of X-rays (from 0.1 to 3 MeV) is equal to 1, whatever the energy or dose rate of the beam. Comparisons of X-ray beam dose rates are scarce even though these beams are widely used in medical diagnosis or radiotherapy. By using two dose rates (0.63 and 2.5 Gy.min

Indexed as

Radiation DosageX-RaysAnimalsCell SurvivalFlow CytometryHumansHuman Umbilical Vein Endothelial CellsIn Vitro TechniquesMiceMice, Inbred C57BLPhantoms, ImagingProof of Concept Study

Identifiers

PMID32341396
PMCPMC7184727
OpenAlexW3019969516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.