Evidence map›Paper›PMID 32341386›Full record

Trial reportScientific reports2020

Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults.

Adrian Wong, Wutao Lou, Kin-Fai Ho, Brian Ka-Fung Yiu, Shi Lin, Winnie Chiu-Wing Chu, Jill Abrigo, Dustin Lee, Bonnie Yin-Ka Lam, Lisa Wing-Chi Au and 7 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Adrian WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wutao LouDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Kin-Fai HoThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
Brian Ka-Fung YiuDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Shi LinDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Winnie Chiu-Wing ChuDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Jill AbrigoDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Dustin LeeStony Brook University School of Medicine, Stony Brook, New York, United States.
Bonnie Yin-Ka LamDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lisa Wing-Chi AuDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yannie Oi-Yan SooDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Alexander Yuk-Lun LauDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Timothy Chi-Yui KwokDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Thomas Wai-Hong LeungDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Linda Chui-Wa LamDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Ko HoDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Vincent Chung-Tong MokDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. vctmok@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate (1) the effects of indoor incense burning upon cognition over 3 years; (2) the associations between indoor incense burning with the brain's structure and functional connectivity of the default mode network (DMN); and (3) the interactions between indoor incense burning and vascular disease markers upon cognitive functions. Community older adults without stroke or dementia were recruited (n = 515). Indoor incense use was self-reported as having burnt incense at home ≥ weekly basis over the past 5 years. Detailed neuropsychological battery was administered at baseline (n = 227) and the Montreal Cognitive Assessment at baseline and year 3 (n = 515). MRI structural measures and functional connectivity of the DMN were recorded at baseline. Demographic and vascular risk factors and levels of outdoor pollutants were treated as covariates. Indoor incense burning was associated with reduced performance across multiple cognitive domains at baseline and year 3 as well as decreased connectivity in the DMN. It interacted with diabetes mellitus, hyperlipidemia and white matter hyperintensities to predict poorer cognitive performance. Indoor incense burning is (1) associated with poorer cognitive performance over 3 years; (2) related to decreased brain connectivity; and (3) it interacts with vascular disease to predispose poor cognitive performance.

Indexed as

CognitionMagnetic Resonance ImagingWhite MatterAdultAgedAged, 80 and overAir Pollution, IndoorChinaCognitive DysfunctionConnectomeFemaleHumansLongitudinal StudiesMaleProspective StudiesRisk Factors

Identifiers

PMID32341386
PMCPMC7184605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.