ArticleNature communications2020
Repurposing a chemosensory macromolecular machine.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Article
- Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography.Nature microbiology · 2023Article
- The Aer2 chemoreceptor from Vibrio vulnificus is a tri-PAS-heme oxygen sensor.Molecular microbiology · 2023Article
- Defining Two Chemosensory Arrays inBiomolecules · 2022Article
- Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches.Biochemical Society transactions · 2022Review
- New Roles for HAMP Domains: the Tri-HAMP Region of Pseudomonas aeruginosa Aer2 Controls Receptor Signaling and Cellular Localization.Journal of bacteriology · 2022Article
- The evolutionary path of chemosensory and flagellar macromolecular machines in Campylobacterota.PLoS genetics · 2022Article
- Structure ofBiomacromolecules · 2022Article
- Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks.Current biology : CB · 2022Article
- Article
- Article
- Leptospira interrogans Aer2: an Unusual Membrane-Bound PAS-Heme Oxygen Sensor.Journal of bacteriology · 2022Article
- The Response Regulator FlmD Regulates Biofilm Formation inMicroorganisms · 2022Article
- Studying bacterial chemosensory array with CryoEM.Biochemical Society transactions · 2021Review
- Diversity of bacterial chemosensory systems.Current opinion in microbiology · 2021Review
- Xenogeneic silencing relies on temperature-dependent phosphorylation of the host H-NS protein in Shewanella.Nucleic acids research · 2021Article
- Review
- Deciphering the Che2 chemosensory pathway and the roles of individual Che2 proteins from Pseudomonas aeruginosa.Molecular microbiology · 2021Article
- Evidence for Pentapeptide-Dependent and Independent CheB Methylesterases.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 5 countries.
Funding
Abstract
How complex, multi-component macromolecular machines evolved remains poorly understood. Here we reveal the evolutionary origins of the chemosensory machinery that controls flagellar motility in Escherichia coli. We first identify ancestral forms still present in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis and Methylomicrobium alcaliphilum, characterizing their structures by electron cryotomography and finding evidence that they function in a stress response pathway. Using bioinformatics, we trace the evolution of the system through γ-Proteobacteria, pinpointing key evolutionary events that led to the machine now seen in E. coli. Our results suggest that two ancient chemosensory systems with different inputs and outputs (F6 and F7) existed contemporaneously, with one (F7) ultimately taking over the inputs and outputs of the other (F6), which was subsequently lost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.