ArticleeNeuro
Neural Differentiation is Moderated by Age in Scene-Selective, But Not Face-Selective, Cortical Regions.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Effects of age on memory-related category-selective connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Encoding-related fMRI BOLD activity predicts subsequent memory for studied scenes, but not subsequent identification of perceptually similar lures.bioRxiv : the preprint server for biology · 2026Article
- Age-related differences in spatial memory occur alongside reduced visual fMRI BOLD but preserved viewpoint-specific scene representations.bioRxiv : the preprint server for biology · 2026Article
- The relationship between category-level neural differentiation and exploratory eye movements in healthy young and older adults.Neurobiology of aging · 2025Article
- Effects of age on the strategic control of recollected content as reflected by modulation of neural correlates of scene retrieval.Neurobiology of aging · 2025Article
- Effects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults.Science advances · 2025Article
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- Age-related differences in perceptual and mental imagery abilities.Frontiers in psychology · 2025Article
- Dissociative Effects of Age on Neural Differentiation at the Category and Item Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Age differences in neural distinctiveness during memory encoding, retrieval, and reinstatement.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age.Neuron · 2023Review
- Representing the Good and Bad: fMRI signatures during the encoding of multisensory positive, negative, and neutral events.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Age-related neural dedifferentiation for individual stimuli: an across-participant pattern similarity analysis.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- The Retrieval-Related Anterior Shift Is Moderated by Age and Correlates with Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Structural impairments in hippocampal and occipitotemporal networks specifically contribute to decline in place and face category processing but not to other visual object categories in healthy aging.Brain and behavior · 2021Article
- Effects of age on goal-dependent modulation of episodic memory retrieval.Neurobiology of aging · 2021Article
- Tracking Age Differences in Neural Distinctiveness across Representational Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Age Differences In Retrieval-Related Reinstatement Reflect Age-Related Dedifferentiation At Encoding.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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Abstract
The aging brain is characterized by neural dedifferentiation, an apparent decrease in the functional selectivity of category-selective cortical regions. Age-related reductions in neural differentiation have been proposed to play a causal role in cognitive aging. Recent findings suggest, however, that age-related dedifferentiation is not equally evident for all stimulus categories and, additionally, that the relationship between neural differentiation and cognitive performance is not moderated by age. In light of these findings, in the present experiment, younger and older human adults (males and females) underwent fMRI as they studied words paired with images of scenes or faces before a subsequent memory task. Neural selectivity was measured in two scene-selective (parahippocampal place area (PPA) and retrosplenial cortex (RSC)] and two face-selective [fusiform face area (FFA) and occipital face area (OFA)] regions using both a univariate differentiation index and multivoxel pattern similarity analysis. Both methods provided highly convergent results, which revealed evidence of age-related reductions in neural dedifferentiation in scene-selective but not face-selective cortical regions. Additionally, neural differentiation in the PPA demonstrated a positive, age-invariant relationship with subsequent source memory performance (recall of the image category paired with each recognized test word). These findings extend prior findings suggesting that age-related neural dedifferentiation is not a ubiquitous phenomenon, and that the specificity of neural responses to scenes is predictive of subsequent memory performance independently of age.
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